Increased intracortical bone remodeling during lactation in beagle dogs.
Increased intracortical bone remodeling during lactation in beagle dogs.
复制标题
比格犬哺乳期间皮质内骨重塑增加。
DOI：
10.1095/biolreprod61.6.1439
复制
发表时间：
1999
影响因子：
3.6
通讯作者：
Miller,SC
中科院分区：
文献类型：
--
作者：
Vajda,EG;Kneissel,M;Muggenburg,B;Miller,SC
在怀孕和哺乳期间，骨骼和矿物质代谢发生了重大变化。本研究的目的是确定比格犬哺乳期间皮质内骨重建和转换的变化。股骨和肋骨，获得了接近哺乳期结束或断奶后不久，与非哺乳期对照犬。肋骨皮质骨的骨转换率远高于股骨干皮质骨。单标记骨单位的数量和吸收空间的数量显着更大，在哺乳期间在肋骨和股骨。此外，哺乳期犬股骨皮质骨的矿物质沉积率、基本多细胞单位激活频率和骨转换率均高于对照组。这些数据表明，在哺乳期，皮质内骨重塑增加，这可能提供了一种机制，骨骼是响应母亲的钙需求。此外，这些数据可能有助于解释皮质骨矿物质密度的短暂下降，据报道，发生在人类哺乳期。
There are substantial changes in skeletal and mineral metabolism during pregnancy and lactation. The purpose of this study was to determine the changes in intracortical bone remodeling and turnover during lactation in beagle dogs. A femur and rib were obtained from dogs near the end of lactation or soon after weaning and compared with nonlactating controls. Rib cortical bone had much higher bone turnover rates than did femoral diaphyseal cortical bone. The number of single-labeled osteons and the number of resorption spaces were significantly greater during lactation in both the rib and the femur. Additionally, the mineral apposition rate, basic multicellular unit activation frequency, and bone turnover rates were greater in the femoral cortical bone from the lactating dogs than from the controls. These data demonstrate that during lactation, intracortical bone remodeling increases, and this may provide a mechanism for the skeleton to be responsive to the calcium requirements of the mother. In addition, these data may help explain the transient decreases in cortical bone mineral density that are reported to occur during human lactation.