Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age.
Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age.
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5 至 89 岁白种人钠锂逆转运和血压的分布。
DOI：
10.1161/01.hyp.13.4.378
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sing,CF
中科院分区：
文献类型：
--
作者：
Turner,ST;Weidman,WH;Michels,VV;Reed,TJ;Ormson,CL;Fuller,T;Sing,CF
病例对照研究表明，红细胞钠-锂逆向转运增加可能预示着原发性高血压的易感性增加。为了研究钠锂逆向转运的个体间差异及其与血压水平的关系，我们研究了明尼苏达州罗切斯特市学校的266户有子女的高加索人1,475人，年龄在5岁到之间(男711人，女764人)。服用降压药或雌孕激素组合的个体不包括在样本中。对年龄的三次多项式回归仅能解释钠锂反转运的一小部分变异性(男性2.8%，p<0.001；女性2.1%，p<0.001)，而关于年龄的四阶回归对收缩压(男性45.7%，p<0.001；女性52.5%，p<0.001)和舒张压(男性39.8%，p<0.001；女性33.0%，P<0.001)。在所有年龄段，男性的钠锂反转运平均值高于女性；但男性和女性的收缩压和舒张压平均值的排名顺序与年龄有关。在5-19.9岁、20-49.9岁和50-89.9岁的男性和女性人群中，年龄、身高和体重调整后的钠锂反转运的正偏态分布可以通过假设两个部分重叠的钠锂反转运分布的混合而不是单一的正态分布(p<0.01)来更好地解释。在20-49.9岁年龄组的男性中，上分布的调整后钠锂反转运值与较高的收缩压和舒张压(平均值+/-SD)有关(收缩压：115+/-11vs.111+/-11 mm Hg，p<0.07；舒张压：71.2+/-8.0vs.68.4+/-8.6 mm Hg，p<0.08)。在50-89.9岁年龄段的女性中，上分布的钠锂反转运调整值与舒张压显著高于下分布的舒张压(77+/-10vs.70+/-9 mm Hg，p<0.03)。
Case-control studies suggest that increased erythrocyte sodium-lithium countertransport may predict increased susceptibility to the development of essential hypertension. To characterize interindividual variation in sodium-lithium countertransport and its relation to blood pressure levels in the general population, we studied 1,475 Caucasians between 5 and 89 years of age (711 males and 764 females) ascertained through 266 households with children in the schools of Rochester, Minnesota. Individuals who were taking antihypertensive agents or combinations of estrogen and progesterone were not included in the sample. A third-order polynomial regression on age accounted for only a small fraction of variability in sodium-lithium countertransport (2.8% in males, p less than 0.001; 2.1% in females, p less than 0.01), whereas a fourth-order regression on age accounted for a large proportion of variability in systolic blood pressure (45.7% in males, p less than 0.001; 52.5% in females, p less than 0.001) and diastolic blood pressure (39.8% in males, p less than 0.001; 33.0% in females, p less than 0.001). Mean sodium-lithium countertransport was higher in males than females at all ages; but the rank order of male and female means for systolic and diastolic blood pressure was age dependent. Positively skewed distributions for age-, height-, and weight-adjusted sodium-lithium countertransport in male and female cohorts between 5-19.9, 20-49.9, and 50-89.9 years of age were explained significantly better by postulating a mixture of two partially overlapping sodium-lithium countertransport distributions rather than a single normal distribution (p less than 0.01). Among men in the 20-49.9-year-old cohort, adjusted sodium-lithium countertransport values in the upper distribution were associated with higher systolic and diastolic blood pressure (mean +/- SD) than values in the lower distribution (for systolic blood pressure: 115 +/- 11 vs. 111 +/- 11 mm Hg, p less than 0.07; for diastolic blood pressure: 71.2 +/- 8.0 vs. 68.4 +/- 8.6 mm Hg, p less than 0.08). Among females in the 50-89.9-year-old cohort, adjusted sodium-lithium countertransport values in the upper distribution were associated with significantly greater diastolic blood pressure than values in the lower distribution (77 +/- 10 vs. 70 +/- 9 mm Hg, p less than 0.03).(ABSTRACT TRUNCATED AT 400 WORDS)