Neuromagnetic responses to binaural beat in human cerebral cortex
Neuromagnetic responses to binaural beat in human cerebral cortex
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DOI：
10.1152/jn.00859.2005
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发表时间：
2006-10-01
影响因子：
2.5
通讯作者：
Kaga, Kimitaka
中科院分区：
文献类型：
--
作者：
Karino, Shotaro;Yumoto, Masato;Kaga, Kimitaka
人脑皮质对双耳搏动的神经磁学反应。神经生理学杂志96：1927-1938,2006。2006年6月21日首次出版；DOI：10.1152/jn.00859.2005。两个频率略有不同的正弦波出现时，会引起主观波动，称为双耳搏动(BB)。BBS提供了双耳相互作用的经典例子，被认为是从两只耳朵接收输入的中枢听觉通路中的神经相互作用的结果。为了探讨脑电波动的皮质表现，我们在9名正常人身上记录了4.00或6.66赫兹的慢脑电诱发的磁场。这些声场显示出很小的幅度；然而，它们足够强，足以与伴随录音的噪音区分开来。对单通道记录的磁场的频谱分析表明，BBS诱发的反应包含Bb频率的特定频谱成分，该磁场被证实代表对Bb的听觉稳态反应(ASSR)。对BB同步反应的空间分布和最小范数电流估计的分析表明，除听皮层外，顶叶和额叶皮质还存在多个BB ASSR源。同步波形的相位具有很大的变异性，提示BB ASSR本身并不代表耳间相位差(IPD)的变化，而是反映了与BB主观波动相对应的更高阶认知过程。我们的发现证实，通过使用关于IPD的信息，人类大脑皮层的活动可以与缓慢的BB同步。
Neuromagnetic responses to binaural beat in human cerebral cortex. J Neurophysiol 96: 1927-1938, 2006. First published June 21, 2006; doi:10.1152/jn.00859.2005. The dichotic presentation of two sinusoids with a slight difference in frequency elicits subjective fluctuations called binaural beat (BB). BBs provide a classic example of binaural interaction considered to result from neural interaction in the central auditory pathway that receives input from both ears. To explore the cortical representation of the fluctuation of BB, we recorded magnetic fields evoked by slow BB of 4.00 or 6.66 Hz in nine normal subjects. The fields showed small amplitudes; however, they were strong enough to be distinguished from the noise accompanying the recordings. Spectral analyses of the magnetic fields recorded on single channels revealed that the responses evoked by BBs contained a specific spectral component of BB frequency, and the magnetic fields were confirmed to represent an auditory steady-state response (ASSR) to BB. The analyses of spatial distribution of BB-synchronized responses and minimum-norm current estimates revealed multiple BB ASSR sources in the parietal and frontal cortices in addition to the temporal areas, including auditory cortices. The phase of synchronized waveforms showed great variability, suggesting that BB ASSR does not represent changing inter-aural phase differences (IPD) per se, but instead it reflects a higher-order cognitive process corresponding to subjective fluctuations of BB. Our findings confirm that the activity of the human cerebral cortex can be synchronized with slow BB by using information on the IPD.