The descriptive epidemiology of craniopharyngioma
The descriptive epidemiology of craniopharyngioma
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DOI：
10.3171/jns.1998.89.4.0547
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发表时间：
1998-10-01
影响因子：
4.1
通讯作者：
Bruner, JM
中科院分区：
文献类型：
--
作者：
Bunin, GR;Surawicz, TS;Bruner, JM
对象。本文对颅咽管瘤的流行病学进行了综述。美国颅咽管瘤的发病率是根据两个以人群为基础的癌症登记处估计的，其中包括良性和交界性恶性脑肿瘤：美国中央脑肿瘤登记处（CBTRUS）和洛杉矶县癌症监测计划。其他儿童肿瘤的信息可从大特拉华谷儿童肿瘤登记处（GDVPTR）获得。颅咽管瘤的总发病率为每10万人年0.13例，且不因性别或种族而异。按年龄划分呈双峰分布，发病率在儿童（5-14岁）和老年人（CBTRUS 65-74岁，洛杉矶县50-74岁）中最高。生存信息可从GDVPTR和国家癌症数据库（NCDB）获得，NCDB是一个基于医院的报告系统。在NCDB中，5年生存率为80%，随着诊断年龄的增长而下降。儿童生存率较高，近年来有所改善。颅咽管瘤是一种行为不确定的罕见脑肿瘤，发病率为每百万人每年1.3例。在美国，预计每年将发生大约338例这种疾病，其中96例发生在0至14岁的儿童中。
Object. In this report the authors describe the epidemiology of craniopharyngioma.Methods. The incidence of craniopharyngioma in the United States was estimated from two population-based cancer registries that include brain tumors of benign and borderline malignancy: the Central Brain Tumor Registry of the United States (CBTRUS) and the Los Angeles county Cancer Surveillance Program. Information on additional pediatric tumors was available from the Greater Delaware Valley Pediatric Tumor Registry (GDVPTR). The overall incidence of craniopharyngioma was 0.13 per 100,000 person years and did not vary by gender or race. A bimodal distribution by age was noted with peak incidence rates in children (aged 5-14 years) and among older adults (aged 65-74 years in CBTRUS and 50-74 years in Los Angeles county). Survival information was available from GDVPTR and the National Cancer Data Base (NCDB), a hospital-based reporting system. In the NCDB, the 5-year survival rate was 80% and decreased with older age at diagnosis. Survival is higher among children and has improved in recent years.Conclusions. Craniopharyngioma is a rare brain tumor of uncertain behavior that occurs at a rate of 1.3 per million person years. Approximately 338 cases of this disease are expected to occur annually in the United States, with 96 occurring in children from 0 to 14 years of age.