STRUCTURAL FEATURES IMPORTANT FOR SIGMA(1) RECEPTOR-BINDING
STRUCTURAL FEATURES IMPORTANT FOR SIGMA(1) RECEPTOR-BINDING
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DOI：
10.1021/jm00034a020
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发表时间：
1994-04-15
影响因子：
7.3
通讯作者：
HOWIE, KB
中科院分区：
文献类型：
--
作者：
GLENNON, RA;ABLORDEPPEY, SY;HOWIE, KB
阻碍受体研究的两个问题是（i）缺乏高亲和力试剂和iii）最近鉴定出多个受体群体（即，sigma（1）和sigma（2）站点）。最近，已经鉴定了几种高亲和力σ配体，并且已经创造了术语超有效σ配体来描述具有K1值为
Two problems that have hampered a receptor research are (i) a lack of high-affinity agents and iii) the recent identification Of multiple populations of a receptors (i.e., sigma(1) and sigma(2) sites). Recently, several high-affinity sigma ligands have been identified, and the term superpotent sigma ligands has been coined to describe agents with K-i values of