To Be Specific or Not: The Critical Relationship Between Hox And TALE Proteins.
To Be Specific or Not: The Critical Relationship Between Hox And TALE Proteins.
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DOI：
10.1016/j.tig.2016.03.004
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Mann RS
中科院分区：
文献类型：
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作者：
Merabet S;Mann RS
Hox蛋白是关键的调控转录因子，在胚胎的不同组织中起作用，为每个细胞提供特定的空间和时间坐标。这些模式化功能通常依赖于TALE同源结构域类辅因子的存在，其与所有Hox蛋白形成合作的DNA结合复合物。这个家族的辅因子如何有助于Hox蛋白在体内的高度多样性和特异性功能仍然是一个重要的未解决的问题。在这里，我们回顾了最新的进展，了解Hox-TALE功能的分子机制。特别地，我们讨论了DNA形状、DNA结合亲和力和蛋白质-蛋白质相互作用灵活性在决定Hox-TALE特异性中的作用。我们提出了几种模型来解释这些机制是如何相互整合的背景下，许多不同的功能Hox和TALE因子在体内进行。
Hox proteins are key regulatory transcription factors that act in different tissues of the embryo to provide specific spatial and temporal coordinates to each cell. These patterning functions often depend on the presence of the TALE-homeodomain class cofactors, which form cooperative DNA-binding complexes with all Hox proteins. How this family of cofactors contributes to the highly diverse and specific functions of Hox proteins in vivo remains an important unsolved question. Here we review the most recent advances in understanding the molecular mechanisms underlying Hox-TALE function. In particular, we discuss the role of DNA shape, DNA- binding affinity and protein-protein interaction flexibility in dictating Hox-TALE specificity. We propose several models to explain how these mechanisms are integrated with each other in the context of the many distinct functions Hox and TALE factors carry out in vivo.