Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women
Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women
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DOI：
10.1093/jn/131.4.1202
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发表时间：
2001-04-01
影响因子：
4.2
通讯作者：
Kritz-Silverstein, D
中科院分区：
文献类型：
--
作者：
Goodman-Gruen, D;Kritz-Silverstein, D
干预数据表明，补充维生素B2酮具有心脏保护作用;然而，很少有研究检查了常规膳食维生素B2摄入对心血管疾病（CVD）的益处。这项横断面研究检查了日常饮食中的脂肪摄入量与CVD风险因素之间的关系，包括脂质和脂蛋白，体重指数（BMI）和脂肪分布，血压，葡萄糖和胰岛素。受试者为年龄45-74岁的绝经后女性（n = 208），她们参加了一项随机、双盲、安慰剂对照试验的筛选和基线访视，该试验检查了服用阿司匹林的效果。在筛选时，测量总胆固醇、甘油三酯、HDL胆固醇和LDL胆固醇，并评估人口统计学、行为和绝经特征。一个月后，用标准化问卷评估过去一年的饮食摄入量。获得人体测量和血压，并进行75克口服葡萄糖耐量试验。异黄酮的摄入量不因年龄、锻炼、吸烟、教育程度或绝经年限而异。与每日不摄入染料木黄酮的妇女相比，摄入染料木黄酮的妇女的BMI（P趋势= 0.05）、腰围（P趋势= 0.05）和空腹胰岛素（P趋势= 0.07）显著降低。在校正分析中，染料木黄酮、大豆苷元和总胆固醇摄入量均与HDL胆固醇呈正相关（P = 0.05），与攻毒后胰岛素呈负相关（P = 0.05）。这些数据表明，膳食大豆摄入量对绝经后妇女心血管疾病的保护作用。
Intervention data suggest a cardioprotective role for supplemental isoflavones; however, few studies have examined the cardiovascular disease (CVD) benefit of usual dietary isoflavone intake. This cross-sectional study examined the association between usual dietary isoflavone intake and CVD risk factors, including lipids and lipoproteins, body mass index (BMI) and fat distribution, blood pressure, glucose and insulin. Subjects were postmenopausal women (n = 208) aged 45-74 y, who attended screening and baseline visits for a randomized, double-blind, placebo-controlled trial examining the effects of isoflavone use. At screening, total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol were measured, and demographic, behavioral and menopausal characteristics were assessed. One month later, dietary intake over the past year was assessed with a standardized questionnaire. Anthropometric measurements and blood pressure were obtained, and a 75-g oral glucose tolerance test was administered. Isoflavone consumption did not vary by age, exercise, smoking, education or years postmenopausal. Women with high genistein intake had a significantly lower BMI (P-trend = 0.05), waist circumference (P-trend = 0.05) and fasting insulin (P-trend = 0.07) than those with no daily genistein consumption. In adjusted analyses, genistein, daidzein and total isoflavone intake were each positively associated with HDL cholesterol (P = 0.05) and inversely associated with postchallenge insulin (P = 0.05). These data suggest a protective role for dietary soy intake against CVD in postmenopausal women.