Transforming growth factor beta 1 in children with systemic lupus erythematosus: a possible relation with clinical presentation of lupus nephritis
Transforming growth factor beta 1 in children with systemic lupus erythematosus: a possible relation with clinical presentation of lupus nephritis
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DOI：
10.1177/0961203306071873
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
El-Arman, M. M.
中科院分区：
文献类型：
--
作者：
Hammad, A. M.;Youssef, H. M.;El-Arman, M. M.
对32名活动性狼疮患儿的血浆和尿液（潜伏和活动）TGF-β 1水平进行了评估，并与15名年龄和性别相匹配的健康对照组进行了比较。活动性疾病患儿血浆TGF-β 1潜伏期和活性水平均显著低于对照组（P = 0.004和P < 0.001）。血浆活性TGF-β 1与系统性红斑狼疮疾病活动指数呈负相关（r =-0.38，P = 0.03）。活动性疾病患儿尿TGF-β 1潜伏期和活性水平均显著高于对照组（P < 0.001和P = 0.003）。尿TGF-β 1活性与抗dsDNA抗体滴度呈正相关（r = 0.42，P = 0.015），与血清C3水平呈负相关（r =-0.48，P = 0.005）。与无症状性肾炎患者相比，有症状性肾炎患者尿中活性TGF-β 1水平显著升高（P = 0.008）。从这些数据中，我们得出结论，血浆TGF-β 1水平降低可能是活动性狼疮患儿全身免疫功能障碍的一个特征，而肾脏活性TGF-β 1的产生增加似乎在狼疮肾炎的临床表现中起作用。
Plasma and urinary (latent and active) TGF-beta 1 levels were assessed in 32 children with active lupus and compared to 15 healthy controls of matched age and sex. Plasma latent and active TGF-beta 1 levels in children with active disease were significantly lower than controls (P = 0.004 and P < 0.001 respectively). Plasma active TGF-beta 1 correlated negatively with Systemic Lupus Erythematosus Disease Activity Index (r = -0.38, P = 0.03). On the contrary, urinary latent and active TGF-beta 1 levels in children with active disease were significantly higher than controls (P < 0.001 and P = 0.003 respectively). Urinary active TGF-beta 1 levels correlated positively with Anti-ds DNA titre (r = 0.42, P = 0.015) and negatively with serum C3 levels (r = -0.48, P = 0.005). Patients with symptomatic nephritis had significantly elevated urinary active TGF-beta 1 levels in comparison to those with silent nephritis (P = 0.008). From this data we conclude that lowered plasma TGF-beta 1 levels may be a feature of systemic immune dysfunction in children with active lupus while increased renal production of active TGF-beta 1 seems to have a role in the clinical presentation of lupus nephritis.