Loss of otolith function with age is associated with increased postural sway measures.
Loss of otolith function with age is associated with increased postural sway measures.
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DOI：
10.1016/j.neulet.2009.08.057
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发表时间：
2009-11-06
影响因子：
2.5
通讯作者：
Wood SJ
中科院分区：
文献类型：
--
作者：
Serrador JM;Lipsitz LA;Gopalakrishnan GS;Black FO;Wood SJ
失去平衡和增加跌倒风险是与衰老相关的常见问题。前庭功能随着年龄的增长而发生变化，但前庭耳石功能下降对跌倒风险的影响仍不清楚。我们检查了 151 名健康个体（21-93 岁）的平衡（摇摆测量）和耳石反滚动 (OCR) 功能。我们在坚固表面上睁开和闭上眼睛、在泡沫表面上睁开和闭上眼睛以及在 0.005 Hz 的 ±20 度滚动倾斜期间进行 OCR 来评估平衡功能。受试者表现出与年龄相关的 OCR 显着降低和姿势摇摆增加。年龄对女性 OCR 的影响大于男性。 OCR 的降低与闭眼时的内侧晃动测量值密切相关。这种相关性也仅存在于老年人群中，表明衰老本身并不能解释这种影响。 OCR 随着年龄的增长呈线性下降，并且女性的下降速度高于男性。前庭耳石眼功能的丧失与内侧摇摆量的增加有关，这已被证明与跌倒风险的增加有关。这些数据表明，耳石功能丧失会增加老年人跌倒的风险。需要进一步的前瞻性纵向研究来证实这些发现。
Loss of balance and increased fall risk is a common problem associated with aging. Changes in vestibular function occur with aging but the contribution of reduced vestibular otolith function to fall risk remains unknown. We examined a population of 151 healthy individuals (aged 21–93) for both balance (sway measures) and otolith counter-rolling (OCR) function. We assessed balance function with eyes open and closed on a firm surface, eyes open and closed on a foam surface and OCR during ±20 degree roll tilt at 0.005 Hz. Subjects demonstrated a significant age-related reduction in OCR and increased postural sway. The effect of age on OCR was greater in females than males. The reduction in OCR was strongly correlated with the mediolateral measures of sway with eyes closed. This correlation was also present in the elderly group alone, suggesting that aging alone does not account for this effect. OCR decreases linearly with age and at a greater rate in females than males. This loss of vestibular otolith-ocular function is associated with increased mediolateral measures of sway which have been shown to be related to increased risk of falls. These data suggest a role for loss of otolith function in contributing to fall risk in the elderly. Further prospective, longitudinal studies are necessary to confirm these findings.
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