[Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs].
[Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs].
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发表时间：
2000-10
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通讯作者：
X. Zhang;J. Wang
中科院分区：
文献类型：
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作者：
X. Zhang;J. Wang
目的研究豚鼠耳蜗微循环障碍时血迷路屏障通透性的变化。方法采用改良伊文思蓝荧光法，在光化学反应诱导的耳蜗微循环障碍动物模型上，观察血迷路屏障通透性的变化。结果耳蜗微循环障碍时，2 h后伊文思蓝通过血迷路屏障的量为（1.709 ± 0.769）μ g/只，4 h后为（2.849 ± 0.653）μ g/只;结论耳蜗微循环障碍时血迷路屏障通透性增加，血迷路屏障通透性增加可能是导致耳蜗缺血性病变的重要机制之一。
OBJECTIVE To study the changes of blood-labyrinth barrier permeability during cochlea microcirculatory disorders in guinea pigs. METHODS Using modified method of Evan's blue fluorescence, the changes of permeability of blood-labyrinth barrier were observed in the animal model of cochlea microcirculatory disorders which was induced by photochemical reaction. RESULTS Amount of Evan's blue passing through the blood-labyrinth barrier was (1.709 +/- 0.769) microgram per guinea pig after 2 hours and (2.849 +/- 0.653) microgram per guinea pig after 4 hours when the cochlea was in microcirculatory disorder. CONCLUSION The results indicated that the permeability of blood-labyrinth barrier increased when cochlea microcirculatory disorders occurred and the increase of blood-labyrinth barrier permeability may be one of the important mechanisms which causes the cochlear ischemic lesions.