Adaptive control of movement for neuromuscular stimulation-assisted therapy in a rodent model.
Adaptive control of movement for neuromuscular stimulation-assisted therapy in a rodent model.
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DOI：
10.1109/tbme.2008.2008193
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Jung R
中科院分区：
文献类型：
--
作者：
Kim SJ;Fairchild MD;Iarkov Yarkov A;Abbas JJ;Jung R
脊髓或脑损伤后的神经运动治疗通常试图利用活动依赖性可塑性来促进功能恢复。激活麻痹或轻瘫肌肉的神经肌肉电刺激可以通过激活更多的肌肉质量并通过适当定时的肌梭激活来丰富感觉模式来增强被动辅助治疗。为了能够研究活动依赖性可塑性，先前开发了用于刺激辅助运动疗法的啮齿动物模型。然而，为了有效，这样的系统必须允许长时间的重复运动。在这项研究中，我们实现了一个自适应模式发生器/模式整形器（PG/PS）控制系统的啮齿动物模型的神经运动治疗和评估其能力，以产生准确和可重复的髋关节运动在漫长的会议通过调整激动剂/拮抗剂肌肉对的激活模式。在100个循环的运动试验中，PG/PS控制系统提供了出色的运动跟踪（<10%的误差），但刺激水平稳步增加，以解释肌肉疲劳。在使用间歇性运动范例的试验中（100组五个周期的比赛，中间穿插20秒的休息时间），在较少的刺激下也观察到了出色的表现（<8%的误差），从而表明肌肉疲劳减少。这些结果证明了PG/PS控制系统利用激动剂/拮抗剂肌肉对来控制啮齿动物模型中关节处的运动的能力。在长时间间歇性会话中可重复运动的演示表明，它可能非常适合提供有效的神经运动治疗。
Neuromotor therapy after spinal cord or brain injury often attempts to utilize activity-dependent plasticity to promote functional recovery. Neuromuscular electrical stimulation that activates paralyzed or paretic muscles may enhance passive assistance therapy by activating more muscle mass and enriching the sensory pattern with appropriately timed muscle spindle activation. To enable studies of activity-dependent plasticity, a rodent model for stimulation-assisted locomotor therapy was developed previously. To be effective, however, such a system must allow lengthy sessions of repetitive movements. In this study, we implemented an adaptive pattern generator/pattern shaper (PG/PS) control system for a rodent model of neuromotor therapy and evaluated its ability to generate accurate and repeatable hip movements in lengthy sessions by adjusting the activation patterns of an agonist/antagonist muscle pair. In 100-cycle movement trials, the PG/PS control system provided excellent movement tracking (<10% error), but stimulation levels steadily increased to account for muscle fatigue. In trials using an intermittent movement paradigm (100 sets of five-cycle bouts interspersed by 20-s rest periods), excellent performance (<8% error) was also observed with less stimulation, thus indicating reduced muscle fatigue. These results demonstrate the ability of the PG/PS control system to utilize an agonist/antagonist muscle pair to control movement at a joint in a rodent model. The demonstration of repeatable movements over lengthy intermittent sessions suggests that it may be well suited to provide efficient neuromotor therapy.