Size of cell-surface Kv2.1 domains is governed by growth fluctuations.
Size of cell-surface Kv2.1 domains is governed by growth fluctuations.
复制标题
细胞表面 Kv2.1 域的大小受生长波动的控制。
DOI：
10.1016/j.bpj.2012.09.013
复制
发表时间：
2012
影响因子：
3.4
通讯作者：
Krapf,Diego
中科院分区：
文献类型：
--
作者：
Weigel,AubreyV;Fox,PhilipD;Akin,ElizabethJ;Ecklund,KariH;Tamkun,MichaelM;Krapf,Diego
Kv2.1电压门控钾通道在不同哺乳动物细胞的表面上形成稳定的簇。尽管这些细胞表面结构已经被观察了近十年，但人们对细胞维持它们的机制知之甚少。我们测量畴尺寸的分布来研究它们的生长动力学。使用Fokker-Planck形式主义，我们发现没有证据的反馈机制，以保持特定的域半径。相反，Kv2.1簇的大小与域大小由贩运机制的波动建立的模型一致。这些结果进一步验证使用的可能性和赤池权重，以选择与我们的实验数据相一致的域生长的动力学的最佳模型。
The Kv2.1 voltage-gated potassium channel forms stable clusters on the surface of different mammalian cells. Even though these cell-surface structures have been observed for almost a decade, little is known about the mechanism by which cells maintain them. We measure the distribution of domain sizes to study the kinetics of their growth. Using a Fokker-Planck formalism, we find no evidence for a feedback mechanism present to maintain specific domain radii. Instead, the size of Kv2.1 clusters is consistent with a model where domain size is established by fluctuations in the trafficking machinery. These results are further validated using likelihood and Akaike weights to select the best model for the kinetics of domain growth consistent with our experimental data.
膜蛋白的动态斑块。
影响因子：
3.4
作者：
Lavi,Yael;Edidin,MichaelA;Gheber,LeviA
通讯作者：
Gheber,LeviA
影响因子：
3.4
作者：
Cheezum, MK;Walker, WF;Guilford, WH
通讯作者：
Guilford, WH