UREAPLASMA-UREALYTICUM INTRAUTERINE INFECTION - ROLE IN PREMATURITY AND DISEASE IN NEWBORNS
UREAPLASMA-UREALYTICUM INTRAUTERINE INFECTION - ROLE IN PREMATURITY AND DISEASE IN NEWBORNS
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DOI：
10.1128/cmr.6.1.69-87.1993
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发表时间：
1993-01-01
影响因子：
36.8
通讯作者：
HARASAWA, R
中科院分区：
文献类型：
--
作者：
CASSELL, GH;WAITES, KB;HARASAWA, R
解脲脲原体是性成熟人群泌尿生殖道的常见病原体，是妊娠期重要的机会致病菌。虽然其病因学意义在不良妊娠的许多方面仍然存在争议，最近的证据表明，美国。在没有其他微生物的情况下，解脲支原体是绒毛膜炎的一个原因。此外，绒毛膜羊膜的脲原体感染与早产和分娩显著相关。至少在某些情况下，它似乎是因果关系。目前的证据表明，美国。溶脲菌是新生儿，特别是早产儿败血症、脑膜炎和肺炎的病因。有强有力但非确定性的证据表明，极低出生体重儿的下呼吸道支原体感染可导致慢性肺部疾病的发展。虽然下泌尿生殖道定植的危险因素已经确定，但关于宫内感染的危险因素和宿主对侵入性感染的免疫反应的信息很少。最近建立的呼吸系统和中枢神经系统疾病的动物模型应该提供一个机会，以评估危险因素，致病机制，和操作的免疫机制。然而，最关键的需要是关于诊断和治疗的适应症以及治疗效果的额外信息。
Ureaplasma urealyticum, a common commensal of the urogenital tract of sexually mature humans, is gaining recognition as an important opportunistic pathogen during pregnancy. While its etiologic significance in many aspects of adverse pregnancy remains controversial, recent evidence indicates that U. urealyticum in the absence of other organisms is a cause of chorioamnionitis. Furthermore, ureaplasmal infection of the chorioamnion is significantly associated with premature spontaneous labor and delivery. In at kast some cases, it appears to be causal. Present evidence indicates that U. urealyticum is a cause of septicemia, meningitis, and pneumonia in newborn infants, particularly those born prematurely. There is strong but not definitive evidence that ureaplasmal infection of the lower respiratory tract can lead to development of chronic lung disease in very low-birth-weight infants. Although risk factors for colonization of the lower genitourinary tract have been identified, little information is available concerning risk factors for intrauterine infection and host immune responses to invasive infection. Recent establishment of animal models of respiratory and central nervous system diseases should provide an opportunity to evaluate risk factors, pathogenic mechanisms, and operative immune mechanisms. However, the most critical need is additional information concerning indications for diagnosis and treatment as well as efficacy of treatment.