On the axial location of Gunn's dots.
On the axial location of Gunn's dots.
复制标题
冈恩点的轴向位置。
DOI：
10.1016/j.ajoc.2020.100757
复制
发表时间：
2020
影响因子：
--
通讯作者：
Saeedi,Osamah
中科院分区：
文献类型：
--
作者：
Hammer,DanielX;Liu,Zhuolin;Cava,JennaA;Carroll,Joseph;Saeedi,Osamah
PurposeTo determine the axial location of古恩dots in the retina.MethodsAdaptive optics scanning laser ophthalmoscopy（AOSLO）images and adaptive optics - optical coherence tomography（AO-OCT）volumes were collected from a region where古恩dots was found inferior to the optic disc from a subject by clinical examination to be a glaucoma suspect.还沿着水平和垂直子午线收集了六名健康受试者和一名青光眼受试者的AO-OCT体积，以识别和记录其他古恩点的出现。AO-OCT体积在三维中记录并取平均值。古恩点进行分割，其体积，面积和直径measured.ResultsAll古恩点成像在这项研究中，从所有的科目被限制在内界膜，既不延伸到玻璃体，也不进入神经纤维层。这些点的大小变化很大。测量的体积，面积和直径（平均值±标准差）分别为1119.9 ± 590.9 μm3，220.2 ± 105.5 μm2，和14.3 ± 3.1 μm，后者的范围内，如以前发表的reports.ConclusionsBased从这项研究和其他证据，古恩点不被认为是米勒细胞终足或透明细胞。我们假设它们与小胶质细胞有关，要么是它们吞噬功能的副产品，要么是实际死亡的阿米巴状小胶质细胞，它们在视网膜病理学中发挥了清道夫的作用。需要对患病眼睛进行进一步研究，以确定它们是否具有预测价值。
PurposeTo determine the axial location of Gunn's dots in the retina.MethodsAdaptive optics scanning laser ophthalmoscopy (AOSLO) images and adaptive optics – optical coherence tomography (AO-OCT) volumes were collected from a region where Gunn's dots were found inferior to the optic disc from a subject determined by clinical examination to be a glaucoma suspect. AO-OCT volumes were also collected along the horizontal and vertical meridians from six healthy subjects and one glaucoma subject to identify and document other occurrences of Gunn's dots. AO-OCT volumes were registered in three-dimensions and averaged. Gunn's dots were segmented, and their volume, area, and diameter were measured.ResultsAll Gunn's dots imaged in this study from all subjects were confined to the inner limiting membrane, neither extending into the vitreous nor into the nerve fiber layer. The size of the dots was highly variable. The measured volume, area, and diameter (mean ± standard deviation) were 1119.9 ± 590.9 μm3, 220.2 ± 105.5 μm2, and 14.3 ± 3.1 μm, the latter within the range as previously published reports.ConclusionsBased upon evidence from this study and others, Gunn's dots are not thought to be Müller cell end-feet or hyalocytes. We hypothesize that they are related to microglia, either as the by-product of their phagocytosis function, or are actual dead ameboid-shaped microglia who have fulfilled their scavenger role in retinal pathology. Further studies are needed in diseased eyes to determine if they have predictive value.