Fluid Mechanics of Blood Clot Formation.
Fluid Mechanics of Blood Clot Formation.
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DOI：
10.1146/annurev-fluid-010814-014513
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发表时间：
2015-01-01
影响因子：
27.7
通讯作者：
Neeves KB
中科院分区：
文献类型：
--
作者：
Fogelson AL;Neeves KB
血管内血凝块在流体动力占主导地位的环境中形成，并且其中流体介导的运输是移动材料的主要手段。凝血系统已经发展到利用流体动力学机制并克服流体动力学挑战，以确保保持血管完整性的凝块可以在循环中发现的广泛流动条件下形成。许多大的可变形红细胞和少数小的刚性血小板之间的液体介导的相互作用导致血管壁附近的高血小板浓度，其中血小板有助于凝血。具有不同动力学和机械特性的受体-配体对协同工作以阻止受损血管上快速流动的细胞。流体动力学应力的变化开启和关闭关键凝血聚合物的功能。蛋白质运输到，从和在一个发展凝块决定是否和如何快速增长。我们回顾正在进行的实验和建模研究，以了解这些和相关的现象。
Intravascular blood clots form in an environment in which hydrodynamic forces dominate and in which fluid-mediated transport is the primary means of moving material. The clotting system has evolved to exploit fluid dynamic mechanisms and to overcome fluid dynamic challenges to ensure that clots that preserve vascular integrity can form over the wide range of flow conditions found in the circulation. Fluid-mediated interactions between the many large deformable red blood cells and the few small rigid platelets lead to high platelet concentrations near vessel walls where platelets contribute to clotting. Receptor-ligand pairs with diverse kinetic and mechanical characteristics work synergistically to arrest rapidly flowing cells on an injured vessel. Variations in hydrodynamic stresses switch on and off the function of key clotting polymers. Protein transport to, from, and within a developing clot determines whether and how fast it grows. We review ongoing experimental and modeling research to understand these and related phenomena.