Preparation of Silica-Based Superficially Porous Silica and its Application in Enantiomer Separations: a Review
Preparation of Silica-Based Superficially Porous Silica and its Application in Enantiomer Separations: a Review
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DOI：
10.1007/s41664-021-00155-2
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发表时间：
2021-03
影响因子：
4.7
通讯作者：
Zhong-Chi Liu;Kaijun Quan;Hui Li;Jia Chen;Ming Guan;H. Qiu
中科院分区：
文献类型：
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作者：
Zhong-Chi Liu;Kaijun Quan;Hui Li;Jia Chen;Ming Guan;H. Qiu
色谱基质材料作为色谱固定相的载体，对其色谱特性（包括柱效、稳定性、峰容量等）起着至关重要的作用。近年来，表面多孔二氧化硅（SPS）由于其特殊的结构性质，在提高柱效方面的优异性能而受到广泛重视，被认为是全多孔SiO2（FPS）的真正替代品，并被用来开发新一代高效固定相。为了帮助研究者更好地认识SPS，进一步推动其在色谱领域的应用和发展，本文系统介绍了SPS的快速分离机理、制备方法及其在对映体快速分离分析中的应用，并对SPS的发展前景进行了展望。
Chromatographic substrate material, as a carrier of chromatographic stationary phases, plays a vital role in defining its chromatographic characteristics, including column efficiency, stability, peak capacity and so on. In recent years, superficially porous silica (SPS) was widely valued for its excellent performance in improving the column efficiency due to its special structural properties, which was considered as a real substitute for fully porous SiO2(FPS) and had been used to develop a new generation of highly efficient stationary phase. To help researchers better understand the SPS and further promote its application and development in the field of chromatography, the rapid separation mechanism, preparation method and its applications in the rapid separation and analysis of enantiomers were systematically introduced, and the development prospects of SPS were also prospected in this paper.