Glutathione S-transferase M1 and T1 polymorphisms in Brazilian African descendants
Glutathione S-transferase M1 and T1 polymorphisms in Brazilian African descendants
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DOI：
10.1353/hub.2007.0025
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发表时间：
2007-02-01
期刊：
影响因子：
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通讯作者：
Klautau-Guimaraes, Maria De Nazare
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文献类型：
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作者：
Hiragi, Cassia De Oliveira;De Oliveira, Silviene Fabiana;Klautau-Guimaraes, Maria De Nazare
谷胱甘肽S转移酶基因家族在不同外源物质和内源化合物的生物转化和解毒过程中起着重要作用。该家族的两个多态基因GSTM1和GSTT1存在零等位基因，因此当基因纯合时不会产生相应的酶。这些多态在种群动力学研究中也很有趣，因为它们在不同种族之间有很大的频率差异，在世界各地都有报道。这些等位基因在巴西城市和美洲印第安人中的分布已被描述，但这些研究中没有一项是关于非洲裔农村人口的报告。本研究的目的是分析GSTM1和GSTT1零等位基因在联邦区城市样本(n=91)和四个半隔离的非洲裔人群中的频率分布：Mocambo(n=55)、Rio das Ras(n=117)、Riacho de Sacutiaba(n=34)和Kalunga(n=68)。GSTM1和GSTT1缺失型频率在GSTM1中为17%~35%，GSTT1中为22%~44%。这些价值观与其他非洲人和非洲裔人口中描述的类似。尽管有这样的范围，但在被分析的人群中没有分布差异。GSTM1和GSTT1缺失型频率的组合范围为6%到13%，与欧洲人群相似，提示该种族混杂。这可以被解释为欧洲人对这些非洲裔人口的贡献。关于联邦区的城市人口，我们的结果表明，非洲和欧洲做出了重要贡献。
The glutathione S-transferase gene family has an important role in the biotransformation and detoxification of different xenobiotics and endogenous compounds. Two polymorphic genes of this family, GSTM1 and GSTT1, present null alleles that consequently do not produce the respective enzyme when the genotype is homozygous. These polymorphisms are also interesting for population dynamics studies because they have great frequency variations among different ethnic groups and have been reported worldwide. The distribution of these alleles in urban and Amerindian populations in Brazil has been described, but none of those studies reported on African-descended rural populations. The aim of this study was to analyze the genotype frequency distribution of the GSTM1 and GSTT1 null alleles in an urban sample from the Federal District (n = 91) and in four semi-isolated African-descended populations: Mocambo (n = 55), Rio das Ras (n = 117), Riacho de Sacutiaba (n = 34), and Kalunga (n = 68). The GSTM1 and GSTT1 null genotype frequencies in these populations range from 17% to 35% for GSTM1 and from 22% to 44% for GSTT1. These values are similar to those described in other African and African-descended populations. Despite this range, there is no distribution difference among the analyzed populations. Combined GSTM1 and GSTT1 null genotype frequencies range from 6% to 13% and are similar to European-derived populations, suggesting admixture with this ethnic group. This can be interpreted as a European contribution to these African-descended populations. Regarding the urban population in the Federal District, our results suggest an important African and European contribution.