Serum lipid profile of Parkinson's disease patients: A study from the Northwest of Iran.
Serum lipid profile of Parkinson's disease patients: A study from the Northwest of Iran.
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帕金森病患者的血脂谱：伊朗西北部的一项研究
DOI：
10.22088/cjim.12.2.155
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发表时间：
2021-03
影响因子：
1.4
通讯作者：
Mahjoub S
中科院分区：
文献类型：
--
作者：
Saedi S;Hemmati-Dinarvand M;Barmaki H;Mokhtari Z;Musavi H;Valilo M;Mota A;Mahjoub S
帕金森病（PD）被定义为一种长期的神经系统疾病。低水平的血脂与帕金森病的高风险相关。本研究旨在评估PD患者的血脂浓度，并与健康受试者进行比较。该病例对照研究于2016年2月至2018年9月在伊朗大不里士医科大学进行。本研究包括75名PD患者和75名正常人。血脂组分的血药浓度通过测定总胆固醇（TC）、血清甘油三酯（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）和总胆固醇的浓度来测定。采用SPSS软件对结果进行分析，采用Kolmogorov-Smirnov、卡方检验和学生t检验。PD患者血清TG水平（111.92±8.75 mg/dL）明显低于健康人（123.64±9.97 mg/dL， P=0.008）。此外，我们看到两组之间LDL-C （P=0.001）和TC （P=0.004）水平的重要差异。然而，在研究组之间，血清HDL-C浓度没有观察到任何有意义的差异（P=0.135）。结果显示，PD患者血清TG、LDL-C、TC浓度明显降低。需要进一步的研究来提供有关参与者认知布局和后续行动的全面信息。
Parkinson's disease (PD) is defined as a long-lasting, neurological illness. Low levels of serum lipid fractions are related with a high risk of PD. Current investigation was designed to evaluate the concentration blood lipid fractions in patients suffering from PD and compared with healthy subjects. This case-control study was conducted from February 2016 to September 2018 in Tabriz University of Medical Sciences, Tabriz, Iran. The present investigation consisted of 75 persons who had PD and 75 normal people. The blood levels of lipid fractions were measured by concentrations of total cholesterol (TC), serum triglycerides (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and total cholesterol. The results were analyzed with SPSS software using Kolmogorov-Smirnov, chi-square, and student's t-test. Serum level of TG was remarkably lower in patients with PD (111.92±8.75 mg/dL) compared with healthy subjects (123.64±9.97 mg/dL, P=0.008). Furthermore, we saw an important difference in the level of LDL-C (P=0.001) and TC (P=0.004) between the two groups. However, there was not any observed meaningful difference in the serum concentrations of HDL-C between the studied groups (P=0.135). Our results showed that the serum concentration of TG, LDL-C, and TC are noticeably lower in the PD suffering patients. Further investigations are needed to provide comprehensive information on the participants' cognitive layout and subsequent actions.