Selection and maintenance of spatial information by frontal eye field neurons.
Selection and maintenance of spatial information by frontal eye field neurons.
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DOI：
10.1523/jneurosci.4465-09.2009
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发表时间：
2009-12-16
期刊：
影响因子：
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通讯作者：
Moore T
中科院分区：
文献类型：
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作者：
Armstrong KM;Chang MH;Moore T
自愿关注往往是根据内部维持的目标分配的。最近的证据表明，额眼场（FEF）参与部署的空间注意，即使在没有扫视眼球运动。此外，许多FEF神经元保持对即将发生的扫视的持续表示。然而，持续活动在空间信息的一般维护中的作用及其与空间注意力的关系尚未被探索。我们记录了猴子的单个FEF神经元的反应，这些猴子被训练记住线索位置，以检测在不涉及扫视的任务中嵌入在干扰物中的目标的变化。我们发现，FEF神经元持续编码的线索的位置在整个试验中，无论是在延迟期间，当没有视觉刺激，并在视觉歧视。此外，FEF活性可靠地预测了猴子是否会检测到目标变化。群体分析显示，具有持续活动的FEF神经元比缺乏持续活动的神经元更善于从干扰物中选择目标。这些结果表明，FEF神经元保持空间信息的扫视准备的情况下，并建议，这种维护有助于选择相关的视觉刺激。
Voluntary attention is often allocated according to internally maintained goals. Recent evidence indicates that the frontal eye field (FEF) participates in the deployment of spatial attention, even in the absence of saccadic eye movements. In addition, many FEF neurons maintain persistent representations of impending saccades. However, the role of persistent activity in the general maintenance of spatial information, and its relationship to spatial attention, has not been explored. We recorded the responses of single FEF neurons in monkeys trained to remember cued locations in order to detect changes in targets embedded among distracters in a task that did not involve saccades. We found that FEF neurons persistently encoded the cued location throughout the trial, both during the delay period when no visual stimuli were present, and during visual discrimination. Furthermore, FEF activity reliably predicted whether monkeys would detect the target change. Population analyses revealed that FEF neurons with persistent activity were better at selecting the target from among distracters than neurons lacking persistent activity. These results demonstrate that FEF neurons maintain spatial information in the absence of saccade preparation and suggest that this maintenance contributes to the selection of relevant visual stimuli.