Geographic Variation in the Prevalence of Kaposi Sarcoma-Associated Herpesvirus and Risk Factors for Transmission
Geographic Variation in the Prevalence of Kaposi Sarcoma-Associated Herpesvirus and Risk Factors for Transmission
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DOI：
10.1086/598523
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发表时间：
2009-05-15
影响因子：
6.4
通讯作者：
Whitby, Denise
中科院分区：
文献类型：
--
作者：
de Sanjose, Silvia;Mbisa, Georgina;Whitby, Denise
背景资料。本研究的目的是评估卡波西肉瘤相关疱疹病毒(KSHV)在女性普通人群中的流行情况，以确定该病毒的地理变异和异性传播。这项研究包括来自9个国家的10,963名妇女，她们可以获得有关社会人口学特征和生殖、性和吸烟行为的信息。检测KSHV裂解抗原K8.1和潜伏抗原ORF73的抗体。KSHV的流行范围(定义为检测任何抗原)为3.81%-46.02%，并有显著的地域差异。在尼日利亚，患病率为46.02%；在哥伦比亚，13.32%；在哥斯达黎加，9.81%；在阿根廷，6.40%；在越南胡志明市，15.50%；在越南河内，11.26%；在泰国宋卡，10%；在泰国楠榜，8.63%；在韩国，4.93%；在西班牙，3.65%。在尼日利亚和哥伦比亚等KSHV流行率较高的地理区域，KSHV的患病率随着年龄的增长而略有增加，随着这些地区受试者受教育程度的提高，KSHV的患病率显著下降。KSHV与首次性交年龄、性伴数、子女数、口服避孕药方式、宫颈人乳头瘤病毒DNA感染及吸烟状况无统计学关系。该研究提供了对4大洲不同文化环境中KSHV流行率的可比估计，并提供了性传播KSHV不是普通人群感染的主要来源的证据。
Background. The aim of the present study was to estimate the prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in the female general population, to define geographic variation in and heterosexual transmission of the virus.Methods. The study included 10,963 women from 9 countries for whom information on sociodemographic characteristics and reproductive, sexual, and smoking behaviors were available. Antibodies against KSHV that encoded lytic antigen K8.1 and latent antigen ORF73 were determined.Results. The range of prevalence of KSHV (defined as detection of any antigen) was 3.81%-46.02%, with significant geographic variation noted. In Nigeria, the prevalence was 46.02%; in Colombia, 13.32%; in Costa Rica, 9.81%; in Argentina, 6.40%; in Ho Chi Minh City, Vietnam, 15.50%; in Hanoi, Vietnam, 11.26%; in Songkla, Thailand, 10%; in Lampang, Thailand, 8.63%; in Korea, 4.93%; and in Spain, 3.65%. The prevalence of KSHV slightly increased with increasing age among subjects in geographic areas where the prevalence of KSHV was high, such as Nigeria and Colombia, and it significantly decreased with increases in the educational level attained by subjects in those areas. KSHV was not statistically associated with age at first sexual intercourse, number of sex partners, number of children, patterns of oral contraceptive use, presence of cervical human papillomavirus DNA, or smoking status.Conclusions. The study provides comparable estimates of KSHV prevalence in diverse cultural settings across 4 continents and provides evidence that sexual transmission of KSHV is not a major source of infection in the general population.