INHIBITION OF ENTRY OF HIV-1 IN NEURAL CELL-LINES BY ANTIBODIES AGAINST GALACTOSYL CERAMIDE
INHIBITION OF ENTRY OF HIV-1 IN NEURAL CELL-LINES BY ANTIBODIES AGAINST GALACTOSYL CERAMIDE
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DOI：
10.1126/science.1857969
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发表时间：
1991-07-19
期刊：
影响因子：
56.9
通讯作者：
GONZALEZSCARANO, F
中科院分区：
文献类型：
--
作者：
HAROUSE, JM;BHAT, S;GONZALEZSCARANO, F
虽然CD4分子是人类免疫缺陷病毒(HIV)的主要细胞受体，但一些CD4阴性细胞系容易感染一种或多种HIV毒株。这些发现表明，病毒有不同的进入模式，可能涉及一个或多个受体分子。抗半乳糖基神经酰胺抗体(半乳糖脑苷脂或GalC)可抑制来自神经系统的两种CD4阴性细胞株的病毒内化和感染：U373-MG和SK-N-MC。此外，重组HIV表面糖蛋白gp120与GalC结合，但不与其他糖脂结合。这些结果表明GalC或一种高度相关的分子在HIV进入神经细胞的过程中发挥了作用。
Although the CD4 molecule is the principal cellular receptor for the human immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection with one or more HIV strains. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules. Antibodies against galactosyl ceramide (galactocerebroside, or GalC) inhibited viral internalization and infection in two CD4-negative cell lines derived from the nervous system: U373-MG and SK-N-MC. Furthermore, recombinant HIV surface glycoprotein gp120 bound to GalC but not to other glycolipids. These results suggest a role for GalC or a highly related molecule in HIV entry into neural cells.