The diurnal cortisol cycle and cognitive performance in the healthy old
The diurnal cortisol cycle and cognitive performance in the healthy old
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健康老年人的昼夜皮质醇循环和认知表现
DOI：
10.1016/j.ijpsycho.2010.12.006
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发表时间：
2011-03-01
影响因子：
3
通讯作者：
Clow, A.
中科院分区：
文献类型：
--
作者：
Evans, P. D.;Fredhoi, C.;Clow, A.
认知表现和皮质醇之间的关联已经被各种各样的皮质醇水平和变化的措施，并为认知功能的某些领域比其他更多的报道。在这项研究中，在50名健康老年人（平均年龄74岁; 34名女性/16名男性）中检查了皮质醇分泌测量和认知能力之间的关联。参与者在连续2天内提供了16个精确定时的唾液样本，以确定皮质醇分泌的昼夜曲线。总体认知能力（OCP）是作为一个全面的认知测试的主要组成部分来测量的。在30岁的年龄范围内，年龄和OCP之间存在很强的负相关。年龄和较差的OCP也与皮质醇觉醒反应（CAR）减弱有关，CAR定义为觉醒后0-30分钟的上升，随后皮质醇水平在一天的其余时间内下降幅度较小。部分分析表明，皮质醇下降之间的相关性在一天和OCP是独立的年龄。年龄较大和皮质醇变化较少都与陈述性记忆和执行功能测试中的较差表现特别相关，我们的结论是，在短暂的觉醒后时期，皮质醇水平较高和认知能力较差之间的普遍相关性存在例外。因此，反映觉醒后峰值的上升（CAR）和下降的动态测量可能在帮助解释皮质醇和认知表现之间的联系方面特别突出。最后，我们在不同认知测试中的结果模式表明，皮质醇与认知功能的那些领域之间存在关联，这些领域对海马体和前额叶皮层的完整性至关重要。(C)2010 Elsevier B. V.保留所有权利。
Associations between cognitive performance and cortisol have variously been reported for measures of both cortisol level and change, and for some domains of cognitive functioning more than others. In this study, associations between cortisol secretion measures and cognitive performance were examined in 50 healthy older people (mean age 74 years; 34 F/16 M). Participants provided 16 accurately timed saliva samples over 2 consecutive days to determine diurnal profiles of cortisol secretion. Overall cognitive performance (OCP) was measured as the principal component of a comprehensive battery of cognitive tests.Across a 30 year age range, there was a strong inverse correlation between age and OCP. Age and poorer OCP were also associated with an attenuated cortisol awakening response (CAR), defined as the rise from 0-30 min after awakening, and a subsequent less steep fall in cortisol level over the rest of the day. Partialling analyses, suggested that the correlation between fall in cortisol over the day and OCP was independent of age. Both older age and less cortisol change were particularly related to poorer performance on tests of declarative memory and executive functioning.Our conclusions are that during the short post-awakening period, an exception exists to the generally pertaining association between higher levels of cortisol and poorer cognitive performance. Consequentially dynamic measures reflecting the rise (CAR) and fall from the post-awakening peak may be particularly salient in helping to explain links between cortisol and cognitive performance. Finally our pattern of results across different cognitive tests suggests an association between cortisol and those domains of cognitive functioning which depend crucially on the integrity of the hippocampus and pre-frontal cortex. (C) 2010 Elsevier B.V. All rights reserved.