Multicenter study for Legg-Calve-Perthes disease in Japan
Multicenter study for Legg-Calve-Perthes disease in Japan
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DOI：
10.1007/s00776-006-1021-1
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发表时间：
2006-07-01
影响因子：
1.7
通讯作者：
Imaeda, Toshihiko
中科院分区：
文献类型：
--
作者：
Kim, Wook-Cheol;Hiroshima, Kazuo;Imaeda, Toshihiko
背景日本儿科骨科协会在2000年成立了一个项目团队，通过一项多中心研究来研究儿科骨科疾病。本研究的目的是收集日本Legg-Calve-Perths病(LCPD)的流行病学资料。通过调查收集以下数据：年龄、性别、诊断日期、家族史、运动史、受累部位、症状、疼痛部位、Catterall分级、鲱鱼分级、开始治疗日期、治疗方法、支具时间和Stulberg分级。从1993年1月1日至1995年12月31日，共有711名患者766个髋关节受累。该病的年平均发病率为100000.9/10万。平均发病年龄7岁1个月(2.3~14.3岁)。研究人群的男女比例为6.3：1.0。患侧比(右/左/双侧髋关节)为5.1：6.8：1.0。在这个系列中，两个髋关节都受到了7.7%的影响。根据Stulberg分类，共有211例(69.4%)患者为I型和II型患者(共304例)。对单侧LCPD的6种治疗方法进行了比较，结果6组间无显著差异。有序Logistic回归分析显示，鲱鱼分型、确诊时的年龄和患侧(单侧LCPD)是显著的预测因素。多因素Logistic回归分析显示，手术治疗的预后优于保守治疗，优势比为1.872。日本对LCPD采取了许多遏制方法，本研究没有确定LCPD的最佳治疗方法。然而，总体结果并不比全球报告中的结果更糟糕。
Background The Japanese Pediatric Orthopaedic Association created a project team in 2000 to research pediatric orthopedic disease through a multicenter study. The aim of this study was to collect epidemiological data on Legg-Calve-Perthes disease (LCPD) in Japan.Methods. The following data were collected by a survey: age, sex, date of diagnosis, family history, sports history, affected sites, symptoms, location of pain, Catterall classification, Herring classification, date of treatment initiation, treatment methods, bracing period, and Stulberg classification.Results. A total of 711 patients with 766 affected hips were seen from January 1, 1993 to December 31, 1995. The average annual incidence of LCPD was 0.9/100000. The average age at diagnosis was 7 years 1 month (2.3-14.3 years). The male/female ratio of the study population was 6.3: 1.0. The affected-side ratio (right hip/left hip/both hips) was 5.1:6.8: 1.0. Both hips were affected in 7.7% of this series. By the Stulberg classification there were 211 (69.4%) type I and II patients (of 304 total patients). Six treatment methods for unilateral LCPD were compared, and there were no significant differences in outcome among the six groups. The ordinal logistic regression analysis showed that the Herring classification, age at the time of diagnosis, and the affected side (for unilateral LCPD) were significant predictors. The ordinal logistic regression analysis also showed that operative treatment had a better outcome than conservative treatment, with an odds ratio of 1.872.Conclusions. Many containment methods for LCPD have been performed in Japan, and the optimal treatment method for LCPD was not determined in this study. The overall outcome, however, was not worse than that in worldwide reports.