EICOSANOIDS AND PLATELET-ACTIVATING-FACTOR IN ALLERGIC RESPIRATORY-DISEASES
EICOSANOIDS AND PLATELET-ACTIVATING-FACTOR IN ALLERGIC RESPIRATORY-DISEASES
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DOI：
10.1164/ajrccm/143.5_pt_2.s86
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发表时间：
1991-05-01
期刊：
影响因子：
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通讯作者：
HENDERSON, WR
中科院分区：
文献类型：
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作者：
HENDERSON, WR
花生四烯酸的氧化衍生物（称为类二十烷酸）和血小板激活因子（PAF）是由参与肺部炎症介导的细胞产生的脂质介质。这些化合物具有与这些炎症反应的发病机制相关的有效生物活性。本综述将重点关注这些脂质介质的作用机制和药理作用、它们的细胞来源以及这些产品导致炎症和气道损伤的方式。要讨论的具体产品是白三烯 (LT)、前列腺素 (PG)、血栓素 (Tx) 和 PAP。
Oxygenated derivatives of arachidonic acid (termed eicosanoids) and platelet-activating factor (PAF) are lipid mediators produced by cells involved in the mediation of pulmonary inflammation. These compounds have potent biologic activities relevant to the pathogenesis of these inflammatory reactions. This review will focus on the mechanisms of action and pharmacologic effects of these lipid mediators, their cell sources, and the waysin which these products lead to inflammation and airway injury. Specific products to be discussed are leukotrienes (LT), prostaglandins (PG), thromboxane (Tx), and PAP.