CHROMOSOMAL LOCATION OF HUMAN T-CELL RECEPTOR GENE TI-BETA
CHROMOSOMAL LOCATION OF HUMAN T-CELL RECEPTOR GENE TI-BETA
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DOI：
10.1126/science.6435246
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
REINHERZ, EL
中科院分区：
文献类型：
--
作者：
BARKER, PE;RUDDLE, FH;REINHERZ, EL
一个与人T淋巴细胞受体钛的β链基因相对应的互补DNA[cDNA]探针已被分子克隆。Ti.beta的染色体起源。通过筛选一系列12细胞杂交种(小鼠、小鼠、小白鼠)进行基因测定。(人类)包含重叠的人类染色体子集的DNA。DNA杂交(Southern)实验表明，人Ti.beta。该基因位于7号染色体上，因此与人类的免疫球蛋白基因座或主要组织相容性基因座无关。
A complementary DNA [cDNA] probe corresponding to the .beta.-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti.beta. gene was determined with the cDNA by screening a series of 12 cell hybrid (mouse .times. human) DNA containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti.beta. gene resides on chromosome 7 and is thus not linked to the Ig loci or to the major histocompatibility locus in humans.