Fast track to the neocortex: A memory engram in the posterior parietal cortex
Fast track to the neocortex: A memory engram in the posterior parietal cortex
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DOI：
10.1126/science.aau2528
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发表时间：
2018-11-30
期刊：
影响因子：
56.9
通讯作者：
Schoenauer, M.
中科院分区：
文献类型：
--
作者：
Brodt, S.;Gais, S.;Schoenauer, M.
系统记忆巩固的模型假设有一个快速学习的海马区和一个缓慢发展、稳定的新皮质区。因此，早期新皮质对记忆的贡献被认为反映了海马体驱动的编码活动的在线恢复。相反，我们发现，学习会迅速在人类后顶叶皮质产生持久的记忆印记。我们通过扩散加权磁共振成像以及物体定位学习任务中的脑功能活动来评估微结构的可塑性。我们早在学习后1小时就检测到了新皮质的可塑性，发现它是学习专一性的，能够进行正确的回忆，并与记忆相关的功能活动重叠。这些微结构变化持续了12小时以上。我们的结果表明，新的痕迹可以迅速编码到顶叶皮质，挑战学习缓慢的新皮质的观点。
Models of systems memory consolidation postulate a fast-learning hippocampal store and a slowly developing, stable neocortical store. Accordingly, early neocortical contributions to memory are deemed to reflect a hippocampus-driven online reinstatement of encoding activity. In contrast, we found that learning rapidly engenders an enduring memory engram in the human posterior parietal cortex. We assessed microstructural plasticity via diffusion-weighted magnetic resonance imaging as well as functional brain activity in an object-location learning task. We detected neocortical plasticity as early as 1 hour after learning and found that it was learning specific, enabled correct recall, and overlapped with memory-related functional activity. These microstructural changes persisted over 12 hours. Our results suggest that new traces can be rapidly encoded into the parietal cortex, challenging views of a slow-learning neocortex.