Irreversible Electroporation (IRE) for Prostate Cancer
Irreversible Electroporation (IRE) for Prostate Cancer
复制标题
不可逆电穿孔 (IRE) 治疗前列腺癌
DOI：
10.1007/978-3-030-73565-4_16
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
J. J. de la Rosette
中科院分区：
文献类型：
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作者：
L. Lunelli;O. Cussenot;J. J. de la Rosette
电穿孔是一种新颖的消融技术，有可能克服其他消融方法的主要缺点。它利用在两个或多个电极之间传播的电脉冲在细胞膜上创建“纳米孔”。如果施加的电流达到一定阈值，这些纳米孔就会变成永久性的，导致细胞死亡。不可逆电穿孔 (IRE) 已被证明可以有效且安全地破坏肿瘤细胞，同时保留组织结构并最大限度地减少对血管和重要泌尿系统结构（如神经血管束）的损害。这是一个优势，因为前列腺癌的常规手术和一些消融治疗方案可能会导致尿失禁、勃起功能障碍和肠道损伤的高发生率。这些副作用通常会损害前列腺癌患者的生活质量，并影响患者接受早期、可能治愈的介入治疗的决定。限制这些结构损伤的新疗法有可能改善患者的治疗结果。首次人体研究已证明 IRE 消融前列腺癌的安全性，并显示出令人鼓舞的功能保留率。
Electroporation is a novel ablative technique with the potential to overcome the main disadvantages of other ablative methods. It utilizes electric pulses, traveling between two or more electrodes, to create “nanopores” in the cell membrane. If the applied current reaches a certain threshold, these nanopores become permanent, resulting in cell death. Irreversible electroporation (IRE) has been shown to be effective and safe in destroying tumor cells while sparing tissue architecture and minimizing damage to blood vessels and important urological structures such as neurovascular bundles. This is an advantage because conventional surgical and some ablative treatment options for prostate cancer can have a high incidence of incontinence, erectile dysfunction, and bowel damage. These side effects often impair the quality of life of prostate cancer patients and impact a patient’s decision to undergo early, potentially curative, interventional treatments. New treatments that limit damage to these structures have the potential to improve patient outcomes. The first human studies have proven the safety of IRE for the ablation of prostate cancer and show encouraging rates for preservation of function.