The hippocampus supports both the recollection and the familiarity components of recognition memory
The hippocampus supports both the recollection and the familiarity components of recognition memory
复制标题
DOI：
10.1016/j.neuron.2005.12.020
复制
发表时间：
2006-02-02
期刊：
影响因子：
16.2
通讯作者：
Squire, LR
中科院分区：
文献类型：
--
作者：
Wais, PE;Wixted, JT;Squire, LR
受试者工作特征(ROC)被用来研究再认记忆的成分加工。一些使用这种技术的研究表明，海马体选择性地支持记忆过程，而海马旁回中邻近的皮质支持熟悉过程。我们分析了年轻人、记忆受损患者和年龄匹配的对照组的ROC数据。在年轻人和患者中，ROC的形状以相似的方式从不对称变为对称，作为记忆强度(从强到弱)的函数。此外，一旦总体记忆强度相似，患者ROC的形状是不对称的，并与对照组ROC匹配。这些结果表明，在没有海马体的情况下，决定ROC形状的组成部分过程是起作用的，他们反对海马体选择性地支持记忆过程的观点。
The receiver operating characteristic (ROC) has been used to investigate the component processes of recognition memory. Some studies with this technique have been taken to indicate that the hippocampus selectively supports the process of recollection, whereas adjacent cortex in the parahippocampal gyrus supports the process of familiarity. We analyzed ROC data from young adults, memory-impaired patients with limited hippocampal lesions, and age-matched controls. The shape of the ROC changed in similar ways from asymmetric to symmetric, as a function of the strength of memory (strong to weak) in both the young adults and the patients. Moreover, once overall memory strength was similar, the shape of the patient ROC was asymmetric and matched the control ROC. These results suggest that the component processes that determine the shape of the ROC are operative in the absence of the hippocampus, and they argue against the idea that the hippocampus selectively supports the recollection process.