Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat
Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat
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DOI：
10.1016/s0306-4522(97)00423-5
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发表时间：
1998-03-01
期刊：
影响因子：
3.3
通讯作者：
Marsden, CA
中科院分区：
文献类型：
--
作者：
Fulford, AJ;Marsden, CA
本研究考察了李斯特帽鼠隔离饲养对足震后内侧伏隔核细胞外5-羟色胺的影响及其与条件情绪反应的关系。不可避免的轻度足震与隔离饲养的大鼠内侧伏隔核细胞外5-羟色胺的立即和长期增加有关。在组养大鼠（足震处理）和对照组（无足震）中，细胞外5-羟色胺水平无显著变化。当140分钟后（无电击的测试箱）暴露于情境刺激时，隔离饲养的大鼠伏隔核细胞外5-羟色胺立即且持续增加，然而，情境刺激对组养大鼠内侧伏隔核细胞外5-羟色胺没有显著影响。结果表明，暴露于足震和环境调节通常与内侧伏隔核细胞外5-羟色胺的变化无关，然而，在断奶后暴露于社会隔离的大鼠中，这两种刺激都增加了细胞外5-羟色胺。隔离诱导的内侧伏隔核突触前5-羟色胺功能的增加与先前报道的海马中5-羟色胺释放减少形成对比，因此表明隔离饲养对大脑中5-羟色胺神经元功能的影响不同。内侧伏隔核5-羟色胺功能的变化可能是对应激的生理适应，也可能是继发于另一种神经递质（可能是多巴胺）功能的变化。(c) 1998 ibro。Elsevier Science Ltd.出版。
This study examined the effect of isolation-rearing in the Lister hooded rat on extracellular 5-hydroxytryptamine in the medial nucleus accumbens following footshock and in relation to a conditioned emotional response. Inescapable mild footshock was associated with an immediate and prolonged increase in extracellular 5-hydroxytryptamine in the medial nucleus accumbens of isolation-reared rats. In group-reared rats (footshock-treated) and control groups (no footshock) there was no significant change in extracellular 5-hydroxytryptamine levels. When exposed to the contextual stimulus 140 min later (testing box without shock) there was an immediate and long-lasting increase in extracellular 5-hydroxytryptamine in the nucleus accumbens of the isolation-reared rats, however, the contextual stimulus did not significantly affect extracellular 5-hydroxytryptamine in the medial nucleus accumbens of group-reared rats.The results show that exposure to footshock and conditioning to context are not normally associated with a change in extracellular 5-hydroxytryptamine in the medial nucleus accumbens, however, in rats exposed to social isolation from weaning, both stimuli increase extracellular 5-hydroxytryptamine. The isolation-induced increase in presynaptic serotonergic function in the medial nucleus accumbens contrasts with previous reports of reduced 5-hydroxytryptamine release in the hippocampus and therefore suggests that isolation-rearing differentially affects the function of serotonergic neurons in the brain. The changes in 5-hydroxytryptamine function in the medial nucleus accumbens may represent physiological adaptations to stress or may occur secondary to changes in the function of another neurotransmitter, possibly dopamine. (C) 1998 IBRO. Published by Elsevier Science Ltd.