ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain
ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain
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DOI：
10.1111/j.1471-4159.2006.03714.x
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发表时间：
2006-04-01
影响因子：
4.7
通讯作者：
Chimini, G
中科院分区：
文献类型：
--
作者：
Broccardo, C;Nieoullon, V;Chimini, G
ATP结合盒转运蛋白A2（ABCA 2）可能参与脑固醇稳态，并与早发性阿尔茨海默病相关的概念，使我们探索其神经表达。我们的数据支持并扩展了以前关于少突胶质细胞表达ABCA 2的报道。它们证明ABCA 2（i）位于胞内囊泡中，在转染的细胞中被鉴定为溶酶体相关的细胞器，仅与经典的内溶酶体部分重叠;（ii）是神经祖细胞的标志物，因为它在侧脑室的脑室下区和海马结构的齿状回中表达，这是成人脑中连续神经发生的部位，在胚胎干细胞体外分化的巢蛋白（+）细胞中;（iii）在成年啮齿动物脑中，在GABA能和多巴胺能神经元的亚群中持续存在。考虑到后者是阿尔茨海默病病变的靶点，这些数据为探索ABCA 2功能失调的神经病理学后果提供了新的理论基础。
The notion that the ATP-binding cassette transporter-A2 (ABCA2) may be involved in brain sterol homeostasis and is associated with early onset Alzheimer's disease led us to explore its neural expression. Our data support and extend the previous reports on ABCA2 expression by oligodendrocytes. They evidence that ABCA2 (i) is located in intracellular vesicles, identified in transfected cells as lysosome-related organelles only partially overlapping with classical endolysosomes; (ii) is a marker of neural progenitors as it is expressed in the subventricular zone of the lateral ventricle and the dentate gyrus of the hippocampal formation, sites of continual neurogenesis in the adult brain, and in nestin(+) cells differentiated in vitro from embryonic stem cells; (iii) persists, in the adult rodent brain, in a subset of GABAergic and glutamatergic neurons. Considering that the latter are targets of Alzheimer's lesions, these data provide a new rationale to explore the neuropathological consequences of ABCA2 functional dysregulations.