Production of apoptosis-inducing substances from soybean protein by Clostridium butyricum: Characterization of their toxic effects on human colon carcinoma cells
Production of apoptosis-inducing substances from soybean protein by Clostridium butyricum: Characterization of their toxic effects on human colon carcinoma cells
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DOI：
10.1016/j.canlet.2008.12.006
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发表时间：
2009-05-18
期刊：
影响因子：
9.7
通讯作者：
Kuwahara, Tomomi
中科院分区：
文献类型：
--
作者：
Arimochi, Hideki;Morita, Kyoji;Kuwahara, Tomomi
已知大豆成分的微生物代谢在发酵过程中产生作为化学预防剂的新活性物质，并且预期肠细菌由于在肠道中代谢大豆成分而产生化学预防剂。然后，通过用大豆蛋白培养肠杆菌丁酸梭菌（C butyricum）来制备条件培养基，并检查其对人结肠癌HCT 116细胞的直接作用。条件培养基显示诱导细胞死亡，并建议含有新的凋亡诱导物质。因此，预计肠杆菌在肠道内从食物来源的蛋白质产生抗肿瘤物质。(c)2008爱思唯尔爱尔兰有限公司保留所有权利。
Microbiral metabolism of soybean constituents is known to produce novel active substances as a chemopreventive agent during the fermentation, and enterobacteria are expected to produce chemopreventive agents as a consequence of metabolizing soybean constituents in the intestinal tract. Then, the conditioned medium was prepared by culturing an enterobacterium Clostridium butyricum (C butyricum) with soybean protein, and its direct effect on human colon carcinoma HCT116 cells was examined. The conditioned medium was shown to induce the cell death, and suggested to contain novel apoptosis-inducing substances. Thus, enterobacteria are predicted to produce anti-tumor substances from food-derived proteins within the intestinal tract. (c) 2008 Elsevier Ireland Ltd. All rights reserved.