Candidate gene studies of fibromyalgia: a systematic review and meta-analysis
Candidate gene studies of fibromyalgia: a systematic review and meta-analysis
复制标题
DOI：
10.1007/s00296-010-1678-9
复制
发表时间：
2012-02-01
影响因子：
4
通讯作者：
Song, Gwan Gyu
中科院分区：
文献类型：
--
作者：
Lee, Young Ho;Choi, Sung Jae;Song, Gwan Gyu
本研究的目的是探讨候选基因多态性是否有助于纤维肌痛的易感性。作者对5-羟色胺转运体（5-HTT）基因连锁多态性区域与（5-HTTLPR）S/L等位基因、儿茶酚-O-甲基转移酶（COMT）val 158 Met和5-羟色胺2A（5-HT 2A）受体102 T/C多态性与纤维肌痛易感性，使用以下方法测定：（1）等位基因对比，（2）隐性，（3）显性模型，（4）纯合子对比。我们还对候选基因的现有数据进行了系统回顾。本系统性综述和荟萃分析共考虑了21项单独的比较。在纤维肌痛易感性的研究中确定了17个候选基因和超过35个不同的多态性。5-HTTLPR S/L等位基因和COMT val 158 Met的荟萃分析未能揭示与纤维肌痛的任何关联。然而，对5-HT 2A受体102 T/C多态性的C等位基因、CC + CT基因型和CC与TT基因型的荟萃分析显示与纤维肌痛显著相关。C等位基因与纤维肌痛相关的总OR为1.333（95%CI = 1.053-1.688，P = 0.017）。CC + CT基因型和CC与TT基因型的OR值与C等位基因相同（OR = 1.541，95%CI = 1.032-2.303，P = 0.035; OR = 1.838，95%CI = 1.151-2.936，P = 0.011）。这项荟萃分析表明，5-HT 2A受体102 T/C多态性赋予纤维肌痛的易感性。相反，5-HTTLPR S/L等位基因COMT val 158 Met与纤维肌痛易感性之间没有关联。
The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast of homozygotes. We also performed a systematic review with available data of the candidate genes. A total of 21 separate comparisons were considered in this systematic review and meta-analysis. Seventeen candidate genes and over 35 different polymorphisms were identified in studies on fibromyalgia susceptibility. Meta-analysis of the 5-HTTLPR S/L allele and COMT val158Met failed to reveal any association with fibromyalgia. However, meta-analysis of the C allele, CC + CT genotype, and CC versus TT genotype of the 5-HT2A receptor 102T/C polymorphism showed significant association with fibromyalgia. The overall OR of the association between the C allele and fibromyalgia was 1.333 (95% CI = 1.053-1.688, P = 0.017). The ORs for the CC + CT genotype, and CC versus TT genotype showed the same pattern as that observed for the C allele (OR = 1.541, 95% CI = 1.032-2.303, P = 0.035; OR = 1.838, 95% CI = 1.151-2.936, P = 0.011). This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia. In contrast, no association was found between the 5-HTTLPR S/L allele, COMT val158Met, and susceptibility to fibromyalgia.