The effects on fetal development of high alpha-fetoprotein and maternal smoking.
The effects on fetal development of high alpha-fetoprotein and maternal smoking.
复制标题
高甲胎蛋白和母亲吸烟对胎儿发育的影响。
DOI：
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发表时间：
1999
影响因子：
12.7
通讯作者：
P. Kirkinen
中科院分区：
文献类型：
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作者：
S. Heinonen;M. Ryynänen;P. Kirkinen
目标
本研究确定了母亲在怀孕期间吸烟和母亲血清甲胎蛋白（MSAFP）浓度不明原因升高之间的相互作用导致胎儿生长受损的风险。
方法
这项观察性研究涉及123名怀孕吸烟者，他们在妊娠中期出现了无法解释的MSAFP浓度升高，827名吸烟者的水平正常，471名非吸烟者的水平升高。
结果
通过逻辑回归分析，发现同时吸烟和MSAFP水平升高与早产、小于胎龄儿出生、低出生体重和新生儿护理需求的低基本风险增加相关。
结论
母亲吸烟对不明原因的MSAFP浓度升高的孕妇的胎儿发育有不良影响。这类妊娠应密切监测。
OBJECTIVES
This study determined the risk of impaired fetal growth resulting from the interaction between maternal smoking during pregnancy and unexplained elevated concentrations of maternal serum alpha-fetoprotein (MSAFP).
METHODS
This observational study involved 123 pregnant smokers with unexplained second-trimester elevated concentrations of MSAFP, 827 smokers with normal levels, and 471 nonsmokers with raised levels.
RESULTS
By logistic regression, coincident smoking and elevated MSAFP levels were found to be associated with increases in the low basic risks of prematurity, small-for-gestational-age births, low birthweight, and need for neonatal care.
CONCLUSIONS
Maternal smoking has an adverse effect on fetal development in pregnancies with unexplained elevated MSAFP concentrations. Such pregnancies merit close surveillance.