A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population
A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population
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DOI：
10.1016/j.bbrc.2005.07.110
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发表时间：
2005-09-23
影响因子：
3.1
通讯作者：
Sasazuki, T
中科院分区：
文献类型：
--
作者：
Aoki, M;Yamamoto, K;Sasazuki, T
关联分析是基于候选基因座中的特定等位基因与邻近遗传标记之间的连锁不平衡，已被提出来鉴定赋予多因素疾病易感性的基因。使用受影响的同胞对方法，我们以前映射四个候选染色体区域，1 p32，2 q33-q35，11 p13-p14，和21 q21，胃癌的连锁分析。为了确定参与疾病的基因，我们对位于21 p11 - 21 q22的66个基因进行了基于基因的关联分析，使用126个单核苷酸多态性（SNP）作为遗传标记，在373例患者和250名对照中。我们发现stress 70蛋白伴侣家族成员STCH基因中的5个SNPs与胃癌尤其是非贲门癌相关（P = 0.0005-0.02，OR = 1.44-1.72）。单倍型频率的比较显示TTGGC单倍型与胃癌显著相关（P = 0.0001，优势比= 1.59）。这些结果表明，在日本人口中，STCH可能是一个新的候选人赋予这种疾病的易感性。(c)2005年爱思唯尔公司All rights reserved.
Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33-q35, 11p13-p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11-21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup (P = 0.0005-0.02, odds ratio = 1.44-1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer (P = 0.0001, odds ratio = 1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease. (c) 2005 Elsevier Inc. All rights reserved.