A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat
A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat
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DOI：
10.1016/0166-4328(83)90188-2
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发表时间：
1983-02
影响因子：
2.7
通讯作者：
Robert J. Sutherland;I. Whishaw;Bryan Kolb
中科院分区：
文献类型：
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作者：
Robert J. Sutherland;I. Whishaw;Bryan Kolb
本实验探讨了大鼠的海马体结构是空间能力神经表征的基本结构。将双侧电解损伤、单侧和双侧凯因酸诱导的CA3-CA4损伤、单侧和双侧秋水仙碱诱导的齿状回损伤等不同海马损伤类型的大鼠在Morris水任务中的空间定位与车辆注射组和正常对照组进行比较。这项任务要求老鼠通过在房间内固定的地方找到一个淹没的隐藏平台来逃离冷水。每次试验的起始点随机变化，并且没有可用的局部线索来指示隐藏平台的位置。训练结束后，平台被移动。逃避潜伏期和初始游泳头显示，除单侧ca3损伤组外，所有病变组在寻找平台时均受损，其中齿状损伤大鼠表现出最大的缺陷。当平台被移动时，对照大鼠主要在先前包含平台的池子里游泳，当它在新的位置找到它时，它们表现出明显的饲养习惯。双侧病变组均未表现出这些影响。研究结果与海马体是“空间映射”系统的一部分的观点是一致的。
This experiment examines the notion that in the rat the hippocampal formation is an essential structure in the neurological representation of spatial abilities. Spatial localization by rats with different types of hippocampal damage, including bilateral electrolytic lesions, unilateral and bilateral kainic acid-induced CA3–CA4 lesions, and unilateral and bilateral colchicine-induced dentate gyrus lesions, was compared with vehicle-injected and normal control groups in the Morris water task. The task required the rats to escape from cold water by finding a submerged and hidden platform located at a fixed place within the room. The start point was varied randomly from trial to trial and there were no local cues available to indicate the position of the hidden platform. After training, the platform was moved. Escape latencies and the initial swimming headings revealed that all lesion groups, except the unilateral CA3-damaged group, were impaired at finding the platform: the dentate-damaged rats exhibited the greatest deficit. When the platform was moved the control rats swam mainly in the part of the pool that had previously contained the platform and, on finding it in the new location, they showed a marked dishabituation of rearing. None of the bilateral lesion groups showed these effects.The results are consistent with the notion that the hippocampus forms part of a ‘spatial mapping’ system.