Regional brain volume changes in alcohol-dependent individuals during early abstinence: associations with relapse following treatment
Regional brain volume changes in alcohol-dependent individuals during early abstinence: associations with relapse following treatment
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DOI：
10.1111/adb.12420
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发表时间：
2017-09-01
影响因子：
3.4
通讯作者：
Meyerhoff, Dieter J.
中科院分区：
文献类型：
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作者：
Durazzo, Timothy C.;Mon, Anderson;Meyerhoff, Dieter J.
对酒精使用障碍(AUD)患者的横断面结构磁共振(MR)成像研究报告称，与长期戒酒的患者相比，治疗后复发的患者在治疗开始前的多个大脑区域显示出更大的形态异常，尤其是在额叶。然而，考虑到先前研究的横断面设计，尚不清楚在早期康复过程中，未来戒毒者和复吸者之间的基线形态差异是否保持不变。这项研究的主要目标是确定早期戒酒期间额叶组织容量的恢复是否与长期戒酒有关。我们比较了戒酒后1周和4周的额叶、顶叶、颞叶和枕叶灰质(GM)和白质(WM)的体积，这些人在治疗后12个月内恢复饮酒(Relapers)，以及那些在治疗后持续戒酒超过12个月的人(戒毒者)。在戒酒1周和4周时，戒酒者和释放者在大多数ROI中的GM体积都明显小于对照组，但Relapers的双侧额叶GM体积明显小于戒酒者。对于任何感兴趣的西医区域，均未观察到显著的组间差异。与上次饮酒相比，Relapers患者持续4周的双侧额叶GM体积缺陷可能代表了一种内表型，这种表型使那些对为AUD提供的典型心理社会和药物干预反应更有利的人有所不同。
Cross-sectional structural magnetic resonance (MR) imaging studies of individuals with an alcohol use disorder (AUD) report that those who relapse after treatment, relative to individuals who maintain a period of extended abstinence, show greater morphological abnormalities in multiple brain regions near the inception of treatment, particularly in the frontal lobe. However, given the cross-sectional design of previous studies, it is unclear if the baseline morphological differences between future abstainers and relapsers were maintained over the course of early recovery. The primary goal of this study was to determine if frontal lobe tissue volume recovery during early abstinence is associated with long-term abstinence from alcohol. We compared frontal, parietal, temporal and occipital grey matter (GM) and white matter (WM) volumes, at 1 and 4 weeks of abstinence, among individuals who resumed alcohol consumption within 12 months of treatment (Relapsers) and those who showed sustained abstinence over 12 months following treatment (Abstainers). At 1 and 4 weeks of sobriety, both Abstainers and Relapsers demonstrated significantly smaller GM volumes than Controls in the majority of ROIs, but Relapsers exhibited significantly smaller bilateral frontal GM volumes than Abstainers. No significant group differences were observed for any WM region of interest. The persistent bilateral frontal GM volume deficits in Relapsers over 4 weeks from last alcohol use may represent an endophenotype that differentiates those who respond more favorably to the typical psychosocial and pharmacological interventions provided for AUD.