MicroRNA-144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer
MicroRNA-144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer
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DOI：
10.3892/or.2019.7025
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发表时间：
2019-04-01
期刊：
影响因子：
4.2
通讯作者：
Feng, Shichun
中科院分区：
文献类型：
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作者：
Jiang, Yasu;Cai, Yunhui;Feng, Shichun
本研究的目的是研究microRNA-144（miR-144）在结直肠癌（CRC）中的作用机制及其在肿瘤进展中的作用。结果表明，在CRC中miR-144下调，Anoctamin 1（ANO 1）表达上调。结直肠癌组织中ANO 1和miR-144的表达呈负相关。目前的研究表明，ANO 1的表达上调与低分化和晚期肿瘤淋巴结转移阶段。证实了ANO 1表达的上调激活了表皮生长因子受体/细胞外信号调节激酶信号通路。还证明了miR-144通过靶向ANO 1发挥强的肿瘤抑制作用。因此，miR-144可能具有作为CRC的预后标志物或治疗靶点的潜力。
The aim of the present study was to research the mechanism of action of microRNA-144 (miR-144) in colorectal cancer (CRC) and its role in tumor progression. It was demonstrated that miR-144 was downregulated and anoctamin 1 (ANO1) expression was upregulated in CRC. The expression of ANO1 was negatively associated with that of miR-144 in CRC. The present study indicated that upregulated expression of ANO1 was associated with poor differentiation and advanced tumor-node-metastasis stage. It was verified that upregulation of ANO1 expression activated the epidermal growth factor receptor/extracellular signal-regulated kinase signaling pathway. It was also demonstrated that miR-144 exerts strong tumor-inhibiting effects by targeting ANO1. Therefore, miR-144 may have potential as a prognostic marker or therapeutic target for CRC.