Amniotic fluid and placental stem cells
Amniotic fluid and placental stem cells
复制标题
DOI：
10.1016/j.bpobgyn.2004.07.001
复制
发表时间：
2004-12-01
影响因子：
5.5
通讯作者：
Fauza, D
中科院分区：
文献类型：
--
作者：
Fauza, D
羊水和胎盘是不同干细胞群的独特来源间充质干细胞、造血干细胞、滋养层干细胞，也可能是更原始的干细胞。尽管大部分羊水/羊水和胎盘有共同的胚胎起源，但这两个隔室中发现的干细胞的具体起源仍有待确定。因此，目前还不知道这两个干细胞亚群的全部或部分是否实际上是相同的。来自这两种来源的不同干细胞群体的多谱系潜力已经开始被描述，但仍有许多有待了解。因此，与使用这些细胞相关的临床应用尚未报道也就不足为奇了。然而，许多不同研究小组的丰富实验工作已经引入了许多利用这些细胞的有前途的新治疗概念，如组织工程，细胞移植和基因治疗。
The amniotic fluid and the placenta are unique sources of different populations of stem cells-mesenchymal, hematopoietic, trophoblastic-and, possibly, of more primitive stem cells. Although much of the amniotic cavity/fluid and the placenta share a common embryonic origin, the specific origins of the stem cells found in these two compartments remain to be determined. Accordingly, it is not yet known whether all or part of these two stem-cell subsets are actually the same. The multilineage potential of the different stem cell populations from these two sources has begun to be described but still much remains to be learned. Thus, it is not surprising that clinical applications related to the use of these cells have yet to be reported. Nevertheless, fertile experimental work from many different groups has introduced a number of promising novel therapeutic concepts utilizing these cells, such as in tissue engineering, cell transplantation, and gene therapy.