Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support
Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support
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DOI：
10.2217/epi-2016-0074
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发表时间：
2016-11-01
期刊：
影响因子：
3.8
通讯作者：
Baccarelli, Andrea A.
中科院分区：
文献类型：
--
作者：
Shields, Alexandra E.;Wise, Lauren A.;Baccarelli, Andrea A.
目的：研究儿童期虐待受害与成人NR3C1新区域DNA甲基化水平的关系，情感支持可能是一种修饰剂。材料与方法：295名参与者来自黑人妇女健康研究。使用多变量线性回归模型计算平均甲基化水平百分比的差异。结果如下：报告儿童期虐待受害的妇女表现出较高的平均NR3C1甲基化水平比非虐待妇女，具有明确的剂量反应关系。童年时期的情感支持似乎只会减弱那些遭受最高程度身体虐待和性虐待的妇女之间的联系。结论：报告儿童期虐待的女性中NR3C1平均甲基化较高。进一步的研究是必要的，以澄清是否或在多大程度上童年的情感支持缓冲的关联。
Aim: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. Materials & methods: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. Results: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. Conclusion: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.