Regional brain activation changes and abnormal functional connectivity of the ventrolateral prefrontal cortex during working memory processing in adults with attention‐deficit/hyperactivity disorder
Regional brain activation changes and abnormal functional connectivity of the ventrolateral prefrontal cortex during working memory processing in adults with attention‐deficit/hyperactivity disorder
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DOI：
10.1002/hbm.20665
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发表时间：
2009-07
影响因子：
4.8
通讯作者：
R. Wolf;M. Plichta;F. Sambataro;A. Fallgatter;C. Jacob;K. Lesch;M. Herrmann;C. Schönfeldt-Lecuona;B. Connemann;G. Grön;N. Vasic
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文献类型：
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作者：
R. Wolf;M. Plichta;F. Sambataro;A. Fallgatter;C. Jacob;K. Lesch;M. Herrmann;C. Schönfeldt-Lecuona;B. Connemann;G. Grön;N. Vasic
先前对成人注意缺陷/多动障碍（ADHD）的工作记忆（WM）功能的研究表明，前额叶皮层和小脑的异常激活。尽管已经假设这些区域的激活差异最可能反映了异常的额小脑回路，但迄今为止尚未研究这些大脑网络在认知表现中的功能耦合。在这项研究中，功能磁共振成像（fMRI）和单变量和多变量分析技术被用于研究健康对照（n = 12）和ADHD成人（n = 12）在认知加工过程中的区域激活变化和功能连接差异。在参数言语WM范式中的行为表现在ADHD成人和健康对照组之间没有显著差异。然而，在激活任务的延迟期，ADHD患者在左腹外侧前额叶皮层（VLPFC）以及小脑和枕叶区域的激活程度明显低于健康对照组。在两组中，独立成分分析揭示了包括双侧前额叶、纹状体和扣带区域的功能网络。与健康对照组相比，ADHD成人的双侧VLPFC、前扣带皮层、顶叶上小叶和小脑的连通性显著降低。ADHD成人在右侧前额叶区、左侧扣带回背皮层和左侧楔叶的连通性增加。这些发现表明，ADHD成人在WM加工过程中存在着VLPFC和小脑的区域脑激活缺陷和功能连通性改变，以及前扣带和顶叶皮层的功能连通性异常。Hum Brain map, 2009。©2008 Wiley‐Liss, Inc。
Previous studies on working memory (WM) function in adults with attention‐deficit/hyperactivity disorder (ADHD) suggested aberrant activation of the prefrontal cortex and the cerebellum. Although it has been hypothesized that activation differences in these regions most likely reflect aberrant frontocerebellar circuits, the functional coupling of these brain networks during cognitive performance has not been investigated so far. In this study, functional magnetic resonance imaging (fMRI) and both univariate and multivariate analytic techniques were used to investigate regional activation changes and functional connectivity differences during cognitive processing in healthy controls (n = 12) and ADHD adults (n = 12). Behavioral performance during a parametric verbal WM paradigm did not significantly differ between adults with ADHD and healthy controls. During the delay period of the activation task, however, ADHD patients showed significantly less activation in the left ventrolateral prefrontal cortex (VLPFC), as well as in cerebellar and occipital regions compared with healthy control subjects. In both groups, independent component analyses revealed a functional network comprising bilateral lateral prefrontal, striatal, and cingulate regions. ADHD adults had significantly lower connectivity in the bilateral VLPFC, the anterior cingulate cortex, the superior parietal lobule, and the cerebellum compared with healthy controls. Increased connectivity in ADHD adults was found in right prefrontal regions, the left dorsal cingulate cortex and the left cuneus. These findings suggest both regional brain activation deficits and functional connectivity changes of the VLPFC and the cerebellum as well as functional connectivity abnormalities of the anterior cingulate and the parietal cortex in ADHD adults during WM processing. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.