A Breathable, Passive-Cooling, Non-Inflammatory, and Biodegradable Aerogel Electronic Skin for Wearable Physical-Electrophysiological-Chemical Analysis.
A Breathable, Passive-Cooling, Non-Inflammatory, and Biodegradable Aerogel Electronic Skin for Wearable Physical-Electrophysiological-Chemical Analysis.
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一种透气、被动冷却、非炎症且可生物降解的气凝胶电子皮肤，用于可穿戴物理电生理化学分析。
DOI：
10.1002/adma.202209300
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Khademhosseini,Ali
中科院分区：
文献类型：
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作者：
Zhu,Yangzhi;Haghniaz,Reihaneh;Hartel,MartinC;Guan,Shenghan;Bahari,Jamal;Li,Zijie;Baidya,Avijit;Cao,Ke;Gao,Xiaoxiang;Li,Jinghang;Wu,Zhuohong;Cheng,Xuanbing;Li,Bingbing;Emaminejad,Sam;Weiss,PaulS;Khademhosseini,Ali
通过设计模仿人类皮肤特征和敏感性的新型电子皮肤（E-skin）平台，可以显着改善对人类健康的实时监测。高质量的电子皮肤平台可以同时监测多种生理和代谢生物标志物，而不引起皮肤不适或刺激，这是一个未满足的医疗需求。传统的电子皮肤要么是单功能的，要么是由弹性体薄膜制成的，不包含天然皮肤的关键协同特征，例如单个贴片中的多传感、透气性和热管理功能。在此，设计并演示了一种基于柔性明胶甲基丙烯酰气凝胶（FGA）的生物相容性和可生物降解的电子皮肤贴片，用于非侵入性和连续监测多种感兴趣的生物标志物。利用低温处理和缓慢聚合的优势，FGA 具有高度互连的多孔结构，具有良好的柔韧性、被动冷却能力和超轻特性，使其长时间佩戴舒适。它还提供了许多可渗透的毛细血管通道，用于热湿传递，确保其出色的透气性。因此，基于 FGA 的工程电子皮肤可以通过电生理传感器同时监测体温、水合和生物电势，并通过电化学传感器检测葡萄糖、乳酸和酒精水平。这项工作为下一代电子皮肤平台提供了一种以前从未探索过的材料策略，具有卓越的实用性。
Real‐time monitoring of human health can be significantly improved by designing novel electronic skin (E‐skin) platforms that mimic the characteristics and sensitivity of human skin. A high‐quality E‐skin platform that can simultaneously monitor multiple physiological and metabolic biomarkers without introducing skin discomfort or irritation is an unmet medical need. Conventional E‐skins are either monofunctional or made from elastomeric films that do not include key synergistic features of natural skin, such as multi‐sensing, breathability, and thermal management capabilities in a single patch. Herein, a biocompatible and biodegradable E‐skin patch based on flexible gelatin methacryloyl aerogel (FGA) for non‐invasive and continuous monitoring of multiple biomarkers of interest is engineered and demonstrated. Taking advantage of cryogenic temperature treatment and slow polymerization, FGA is fabricated with a highly interconnected porous structure that displays good flexibility, passive‐cooling capabilities, and ultra‐lightweight properties that make it comfortable to wear for long periods of time. It also provides numerous permeable capillary channels for thermal‐moisture transfer, ensuring its excellent breathability. Therefore, the engineered FGA‐based E‐skin can simultaneously monitor body temperature, hydration, and biopotentials via electrophysiological sensors and detect glucose, lactate, and alcohol levels via electrochemical sensors. This work offers a previously unexplored materials strategy for next‐generation E‐skin platforms with superior practicality.