Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
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DOI：
10.1210/jc.2015-2860
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发表时间：
2016-03-01
影响因子：
5.8
通讯作者：
Accili, Domenico
中科院分区：
文献类型：
--
作者：
Cinti, Francesca;Bouchi, Ryotaro;Accili, Domenico
Context: Diabetes is associated with a deficit of insulin-producing beta-cells. Animal studies show that beta-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage, and partly converting to other endocrine cell types.Objective: To determine whether similar processes occur in human type 2 diabetes, we surveyed pancreatic islets from 15 diabetic and 15 nondiabetic organ donors.Design: We scored dedifferentiation using markers of endocrine lineage, beta-cell-specific transcription factors, and a newly identified endocrine progenitor cell marker, aldehyde dehydrogenase 1A3.Results: By these criteria, dedifferentiated cells accounted for 31.9% of beta-cells in type 2 diabetics vs 8.7% in controls, and for 16.8% vs 6.5% of all endocrine cells (P
