Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants - a Dutch prospective cohort study.
Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants - a Dutch prospective cohort study.
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DOI：
10.1186/1476-069x-13-106
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发表时间：
2014-12-10
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影响因子：
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通讯作者：
van de Bor M
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作者：
de Cock M;de Boer MR;Lamoree M;Legler J;van de Bor M
环境中存在的内分泌干扰物(EDCs)可能会扰乱甲状腺激素，而甲状腺激素在早期生命中对大脑发育至关重要。关于这一主题的观察性研究仍然有限，但由于环境中化学物质的存在无处不在，因此有必要进行进一步的研究。目前这项研究的目的是评估荷兰母子队列中新生儿各种内分泌细胞暴露标志物与甲状腺激素(T4)水平之间的关系。研究人员检测了脐带血或母乳中二氯二苯基二氯乙烯(DDE)、邻苯二甲酸二乙基己酯(DEHP)三种代谢物、六氯苯(HCB)、多氯联苯(PCB153)、全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)的暴露情况，并通过荷兰的新生儿筛查计划获得了足跟刺血斑点中T4水平的信息。线性回归模型被组成来确定每个化合物和T4之间的关联，这些关联是按性别分层的，并根据预先定义的协变量进行调整。平均T4水平为86.9nmol/L(n = 83)。暴露于DDE和全氟辛酸最高四分位数的女孩的T4水平高于粗调和完全调整模型的最低四分位数(DDE >； 107.50 ng/L，+24.8nmol/L，95%CI 0.79，48.75；全氟辛酸 >； 1200ngng/L，+38.6nmol/L，95%CI 13.34，63.83)。在男孩中，全氟辛烷磺酸和全氟辛烷磺酸暴露的第二个四分位数的T4水平较低，然而，在完全调整模型后，这些关联被减弱。没有观察到其他化合物的影响。DDE和全氟烷基酸可能以性别特异性的方式与T4相关。然而，由于研究人群相对较少，因此应谨慎解读这些结果。有必要进行更多的研究，因为关于环境污染物在这一领域的作用的研究仍然有限。本文的在线版本(DOI：10.1186/1476-069X-13-106)包含补充材料，授权用户可以使用。
Endocrine disrupting chemicals (EDCs) present in the environment may disrupt thyroid hormones, which in early life are essential for brain development. Observational studies regarding this topic are still limited, however as the presence of chemicals in the environment is ubiquitous, further research is warranted. The objective of the current study was to assess the association between exposure markers of various EDCs and thyroxine (T4) levels in newborns in a mother-child cohort in the Netherlands. Exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, hexachlorobenzene (HCB), polychlorinated biphenyl (PCB)-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma or breast milk, and information on T4 levels in heel prick blood spots was obtained through the neonatal screening programme in the Netherlands. Linear regression models were composed to determine associations between each of the compounds and T4, which were stratified for gender and adjusted for a priori defined covariates. Mean T4 level was 86.9 nmol/L (n = 83). Girls in the highest quartile of DDE and PFOA exposure showed an increased T4 level compared to the lowest quartile with both crude and fully adjusted models (DDE > 107.50 ng/L, +24.8 nmol/L, 95% CI 0.79, 48.75; PFOA > 1200 ng/L, +38.6 nmol/L, 95% CI 13.34, 63.83). In boys a lower T4 level was seen in the second quartile of exposure for both PFOS and PFOA, however after fully adjusting the models these associations were attenuated. No effects were observed for the other compounds. DDE and perfluorinated alkyl acids may be associated with T4 in a sex-specific manner. These results should however be interpreted with caution, due to the relatively small study population. More research is warranted, as studies on the role of environmental contaminants in this area are still limited. The online version of this article (doi:10.1186/1476-069X-13-106) contains supplementary material, which is available to authorized users.