Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway
Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway
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DOI：
10.1016/j.addr.2023.115130
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发表时间：
2023-11-02
影响因子：
16.1
通讯作者：
Yuan，Hong
中科院分区：
文献类型：
--
作者：
Wang，Ding;Jiang，Qi;Yuan，Hong
口服给药由于其无创性、安全性、方便性和高患者依从性而在临床实践中是优选的药物递送途径。胃肠道（GIT）在促进口服药物的靶向递送中起着至关重要的作用。然而，GIT具有阻碍药物吸收的多种屏障，包括胃中的胃屏障和肠中的粘液和上皮屏障。近几十年来，纳米技术已经成为一种有前途的方法，通过利用基于纳米载体的药物递送系统，如脂质体，胶束，聚合物纳米颗粒，固体脂质纳米颗粒和无机纳米颗粒来克服这些挑战。将药物包封在纳米载体中不仅可以保护药物不被降解，还可以增强药物在GIT中的转运和吸收，最终提高口服生物利用度。本综述的目的是阐明纳米载体介导的跨GIT转运通过血液循环和淋巴途径进入体循环的机制。
Oral administration is the preferred route of drug delivery in clinical practice due to its noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal tract (GIT) plays a crucial role in facilitating the targeted delivery of oral drugs. However, the GIT presents multiple barriers that impede drug absorption, including the gastric barrier in the stomach and the mucus and epithelial barriers in the intestine. In recent decades, nanotechnology has emerged as a promising approach for overcoming these challenges by utilizing nanocarrier-based drug delivery systems such as liposomes, micelles, polymeric nanoparticles, solid lipid nanoparticles, and inorganic nanoparticles. Encapsulating drugs within nanocarriers not only protects them from degradation but also enhances their transport and absorption across the GIT, ultimately improving oral bioavailability. The aim of this review is to elucidate the mechanisms underlying nanocarrier-mediated transportation across the GIT into systemic circulation via both the blood circulation and lymphatic pathway.