Is adrenomedullin a causal agent in some cases of type 2 diabetes?
Is adrenomedullin a causal agent in some cases of type 2 diabetes?
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DOI：
10.1016/s0196-9781(99)00158-8
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发表时间：
1999-12-01
期刊：
影响因子：
3
通讯作者：
Cuttitta, F
中科院分区：
文献类型：
--
作者：
Martínez, A;Elsasser, TH;Cuttitta, F
对两个新近发病的2型糖尿病患者的研究表明，其中一部分患者的肾上腺髓质素（AM）水平高于其他糖尿病患者。在这个亚群中，AM的生理升高可能在易感个体中引发了疾病。糖尿病患者的AM水平高于健康对照组。此外，糖尿病大鼠注射生理盐水、AM或抗AM抗体后测定血糖。AM使血糖升高，而抗体使循环葡萄糖降至正常水平。这些结果表明，操纵AM水平可能代表了糖尿病管理的一种新方法。Elsevier Science Inc.出版。
The study of two populations with a recent onset of type 2 diabetes showed that a subset of the patients had higher levels of adrenomedullin (AM) than the rest of the diabetics. In this subset, physiological elevations of AM might have triggered the disease in predisposed individuals. Diabetics showed higher levels of AM than healthy controls. In addition, glycemia was measured in diabetic rats after injection of saline, AM, or antiAM antibody. AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals. Published by Elsevier Science Inc.