Trends of female and male breast cancer incidence at the global, regional, and national levels, 1990-2017
Trends of female and male breast cancer incidence at the global, regional, and national levels, 1990-2017
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DOI：
10.1007/s10549-020-05561-1
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发表时间：
2020-02-13
影响因子：
3.8
通讯作者：
Fan, Pingming
中科院分区：
文献类型：
--
作者：
Chen, Zhilin;Xu, Lu;Fan, Pingming
目的乳腺癌是一个全球性的主要公共卫生问题，在男性和女性之间表现出显着的异质性。了解全球男女发病情况对于预防乳腺癌和减少疾病负担至关重要。方法我们从2017年全球疾病负担数据库中检索了男女乳腺癌的发病率数据。平均每年的百分比变化被用来量化乳腺癌发病率的时间趋势。结果1990年至2017年，女性乳腺癌（FBC）新发病例数从87.02万例增加到193.76万例，年龄标化发病率（ASR）从39.2/10万显著增加到45.9/10万。共有166个国家的FBC-ASR显著增加。增长最明显的主要是发展中国家。下降主要发生在几个发达国家，如美国和英国。男性乳腺癌（MBC）是一种罕见的恶性肿瘤，在世界范围内没有明显的聚集性.在全球范围内，新诊断的MBC病例数从1990年的8500例增加到2017年的23100例，ASR从0.46/100，000显著增加到0.61/100，000。共有123个国家的MBC-ASR呈显著上升趋势。结论在大多数国家，乳腺癌的发病率在男女中都在增加，尽管FBC和MBC之间的流行病学特征并不完全相同。应更加重视乳腺癌的一级预防，并且可能需要为FBC和MBC量身定制预防策略。
Purpose Breast cancer is a major public health concern worldwide and shows significant heterogeneity between male and female. Knowing the global incidence landscape in both sexes is critical for the breast cancer prevention and the reduction in disease burden. Methods We retrieved the incidence data of breast cancer in both sexes from the Global Burden of Disease 2017 database. Average annual percentage change was used to quantify the temporal trends of breast cancer incidence. Results Between 1990 and 2017, the number of newly diagnosed female breast cancer (FBC) cases increased from 870.2 thousand to 1937.6 thousand, with the age-standardized incidence rate (ASR) significantly increased from 39.2/100,000 to 45.9/100,000. A total of 166 countries experienced a significant increase in FBC-ASR. The most pronounced increase was mainly found in developing countries. The decrease was mostly detected in several developed countries, such as the USA and the UK. Male breast cancer (MBC) is a rare carcinoma and has no evident cluster across the world. Worldwide, the number of newly diagnosed MBC cases increased from 8.5 thousand in 1990 to 23.1 thousand in 2017, with the ASR significantly increased from 0.46/100,000 to 0.61/100,000. A total of 123 countries showed a significant increasing trend in MBC-ASR. Conclusions Breast cancer incidence rates are increasing in most countries in both sexes, although the epidemiological features were not completely shared between FBC and MBC. More emphases should be placed on breast cancer primary prevention and the prevention strategies might need to be tailored for both FBC and MBC.