NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning.
NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning.
复制标题
视觉皮层中的NMDA受体对于正常的视觉运动整合和技能学习是必需的。
DOI：
10.7554/elife.71476
复制
发表时间：
2022-02-16
期刊：
影响因子：
7.7
通讯作者：
Keller GB
中科院分区：
文献类型：
--
作者：
Widmer FC;O'Toole SM;Keller GB
运动输出与视觉反馈之间的耦合体验是视觉技能发展的必要条件，并形成视皮层的视觉整合。V1中的这些依赖经验的反应变化是否取决于局部电路的修改，或者是V1之外的电路变化的结果，仍然不清楚。在这里，我们探讨了N-甲基-D-天冬氨酸（NMDA）受体依赖的信号，这是已知的参与神经元可塑性，在小鼠初级视觉皮层（V1）在视觉发育过程中的作用。我们使用了本地敲除的NMDA受体和光激活抑制的CaMKII在V1在第一次视觉体验，以探测在V1的神经元活动的变化，以及在视觉任务的性能的影响。我们发现，敲除NMDA受体之前，而不是之后，第一次视觉体验减少了对不可预测的刺激的反应，减少了对V1中可预测反馈的抑制，并损害了以后生活中的视觉技能学习。我们的研究结果表明，NMDA受体依赖的信号在V1是至关重要的，在第一次视觉体验，塑造视觉整合，使视觉技能学习。
The experience of coupling between motor output and visual feedback is necessary for the development of visuomotor skills and shapes visuomotor integration in visual cortex. Whether these experience-dependent changes of responses in V1 depend on modifications of the local circuit or are the consequence of circuit changes outside of V1 remains unclear. Here, we probed the role of N-methyl-d-aspartate (NMDA) receptor-dependent signaling, which is known to be involved in neuronal plasticity, in mouse primary visual cortex (V1) during visuomotor development. We used a local knockout of NMDA receptors and a photoactivatable inhibition of CaMKII in V1 during the first visual experience to probe for changes in neuronal activity in V1 as well as the influence on performance in a visuomotor task. We found that a knockout of NMDA receptors before, but not after, first visuomotor experience reduced responses to unpredictable stimuli, diminished the suppression of predictable feedback in V1, and impaired visuomotor skill learning later in life. Our results demonstrate that NMDA receptor-dependent signaling in V1 is critical during the first visuomotor experience for shaping visuomotor integration and enabling visuomotor skill learning.