Highly Enantio- and Diastereoselective Organocatalytic Desymmetrization of Prochiral Cyclohexanones by Simple Direct Aldol Reaction Catalyzed by Proline
Highly Enantio- and Diastereoselective Organocatalytic Desymmetrization of Prochiral Cyclohexanones by Simple Direct Aldol Reaction Catalyzed by Proline
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DOI：
10.1002/chem.200900488
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发表时间：
2009-01-01
影响因子：
4.3
通讯作者：
Rios, Ramon
中科院分区：
文献类型：
--
作者：
Companyo, Xavier;Valero, Guillem;Rios, Ramon
羟醛脱对称反应的灵丹妙药：我们描述了一种利用不同氢键供体(见图)作为辅助催化剂的4-取代环己酮在Pro催化下脱对称反应的简便方法，大大提高了Pro在脱对称反应中的催化效率。
Panacea for aldol desymmetrizations: We describe an easy entry for the desymmetrization of 4‐substituted‐cyclohexanones catalyzed by proline, using as cocatalysts different hydrogen‐bonding donors (see scheme), which dramatically improves the catalytic efficiency of proline in desymmetrization reactions.