Terahertz pulses induce segment renewal via cell proliferation and differentiation overriding the endogenous regeneration program of the earthworm Eisenia andrei
Terahertz pulses induce segment renewal via cell proliferation and differentiation overriding the endogenous regeneration program of the earthworm Eisenia andrei
复制标题
DOI：
10.1364/boe.416158
复制
发表时间：
2021-04-01
影响因子：
3.4
通讯作者：
Molnar, Laszlo
中科院分区：
文献类型：
--
作者：
Abufadda, Mahmoudh;Erdelyi, Anita;Molnar, Laszlo
太赫兹（THz）照射切除的安氏蚯蚓被证明会导致模型动物的遗传决定的，内源性介导的部分更新能力的覆盖。单周期太赫兹脉冲的5？J能量、0.30 THz平均频率、293 kV/cm峰值电场和1 kHz重复频率刺激细胞增殖（由大量有丝分裂细胞指示）以及组织发生和器官发生，产生显著更高数量的再生节段。太赫兹治疗的动物中最明显的变化是新的中枢神经系统和血管的更强烈的发展。这些结果清楚地表明，太赫兹脉冲能够有效地触发生物过程，并提出了在医学上的潜在应用。
Terahertz (THz) irradiation of excised Eisenia andrei earthworms is shown to cause overriding of the genetically determined, endogenously mediated segment renewing capacity of the model animal. Single-cycle THz pulses of 5 ?J energy, 0.30 THz mean frequency, 293 kV/cm peak electric field, and 1 kHz repetition rate stimulated the cell proliferation (indicated by the high number of mitotic cells) and both histogenesis and organogenesis, producing a significantly higher number of regenerated segments. The most conspicuous alteration in THz-treated animals was the more intense development of the new central nervous system and blood vessels. These results clearly demonstrate that THz pulses are capable to efficiently trigger biological processes and suggest potential applications in medicine.