Effects of diatrizoate and iopamidol on spermatogenesis.
Effects of diatrizoate and iopamidol on spermatogenesis.
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泛影酸盐和碘帕醇对精子发生的影响。
DOI：
10.1097/00004424-199312000-00016
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发表时间：
1993
影响因子：
6.7
通讯作者：
Rao,DV
中科院分区：
文献类型：
--
作者：
Yaghmai,V;Harapanhalli,RS;Patel,YD;Baker,SR;Rao,DV
基本原理和目标。以小鼠睾丸精子发生为实验模型，考察了碘造影剂的生物学效应。以精子存活和异常测定作为生物学终点。以相同的速率和浓度静脉注射三聚氰胺/三聚氰胺钠和iopamidol。通过高效液相色谱技术检测睾丸对这些造影剂的摄取和清除。采用合适的甘露醇溶液作为渗透压对照。静脉注射造影剂或其相应的甘露醇对照导致精子计数减少约30%。一项与甘露醇剂量相关的实验表明，在达到600 mOsm/kg之前，精子计数迅速下降，超过600 mOsm/kg后，这种下降最小。两种造影剂的清除大约在4小时内完成。精子头畸形诱导未见明显增加。渗透性物质，如碘造影剂，影响精子发生的过程。©Lippincott-Raven出版社。回到当前问题封面图像永远不会错过一个问题获取新期刊目录发送到您的电子邮件收件箱获取新问题警报浏览期刊内容
RATIONALE AND OBJECTIVES. The biological effects of iodinated contrast media were examined by using spermatogenesis in mouse testis as the experimental model.METHODS. Spermhead survival and abnormality assays were used as the biological end points. Diatrizoate meglumine/diatrizoate sodium and iopamidol were administered intravenously at equal rates and concentrations. Testicular uptake and clearance of these contrast agents were examined by high-performance liquid chromatography techniques. Appropriate mannitol solutions were employed as osmolality controls.RESULTS. Intravenous administration of the contrast agent or its respective mannitol control resulted in approximately a 30% decrease in spermhead count. A dose-related experiment with mannitol demonstrated that the spermhead count decreased rapidly until 600 mOsm/kg was reached, beyond which this decrease was minimal. Clearance of both contrast media was complete in approximately 4 hours. No significant increase in the induction of spermhead abnormalities was observed.CONCLUSION. Osmotic substances, such as iodinated contrast agents, affect the process of spermatogenesis.© Lippincott-Raven Publishers.Back to TopCurrent Issue Cover ImageNever Miss an IssueGet new journal Tables of Contents sent right to your email inboxGet New Issue AlertsBrowse Journal Content